Title:
NOVEL PIM KINASE INHIBITORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/211256
Kind Code:
A1
Abstract:
The present invention relates to novel PIM kinase inhibitors and uses thereof and, more specifically, to a novel compound having PIM kinase inhibitory activity and a composition for the prevention, amelioration or treatment of diseases related to PIM kinase activity, comprising same. The compound of the present invention was confirmed to have effective PIM kinase inhibitory activity while having low cardiotoxicity, and thus can be effectively used as a composition for the prevention, amelioration or treatment of various diseases related to PIM kinase activity, such as cancer, autoimmune diseases, myeloproliferative disorders, or atherosclerosis.
Inventors:
LEE JINHO (KR)
HONG VICTOR SUKBONG (KR)
KIM SHIN (KR)
LEE CHANG-SEOK (KR)
KIM JONG YUP (KR)
LEE JUNGMEE (KR)
KIM JI EUN (KR)
LEE SANG WOOK (KR)
LIM MI SUN (KR)
PARK YOUN JUN (KR)
HONG VICTOR SUKBONG (KR)
KIM SHIN (KR)
LEE CHANG-SEOK (KR)
KIM JONG YUP (KR)
LEE JUNGMEE (KR)
KIM JI EUN (KR)
LEE SANG WOOK (KR)
LIM MI SUN (KR)
PARK YOUN JUN (KR)
Application Number:
PCT/KR2023/005916
Publication Date:
November 02, 2023
Filing Date:
April 28, 2023
Export Citation:
Assignee:
JEIL PHARMACEUTICAL CO LTD (KR)
UNIV KEIMYUNG IACF (KR)
UNIV KEIMYUNG IACF (KR)
International Classes:
C07D401/04; A61K31/4545; A61K31/496; A61K31/5377; A61K31/55; A61K31/553; A61P9/10; A61P35/00; A61P37/00; C07D405/14
Domestic Patent References:
| WO2007131201A2 | 2007-11-15 |
Foreign References:
| KR20160128420A | 2016-11-07 | |||
| US20140249135A1 | 2014-09-04 | |||
| US9452995B2 | 2016-09-27 | |||
| US20130029971A1 | 2013-01-31 |
Attorney, Agent or Firm:
YOU ME PATENT AND LAW FIRM (KR)
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