Title:
NOVEL PIPERAZINE DERIVATIVE OR SALT THEREOF AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2024/043334
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a compound and pharmaceutical composition that possesses inhibitory activity against the drug efflux pumps of drug-resistant bacteria and, when used in combination with another drug, can restore the antibacterial activity of said other drug. The present invention provides a compound represented by general formula [1] (the symbols are as defined in the description) or a salt thereof and a pharmaceutical compound comprising these.
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Inventors:
DOI ISSEI (JP)
FUJIWARA MASASUKE (JP)
FURUYA KENTARO (JP)
NAKAE TOMOFUMI (JP)
TANAKA KEITA (JP)
NISHINO KUNIHIKO (JP)
YAMASAKI SEIJI (JP)
NAKASHIMA RYOSUKE (JP)
SUZUKI TAKAYOSHI (JP)
TAKADA YURI (JP)
NAKAGAWA ATSUSHI (JP)
YAMASHITA EIKI (JP)
FUJIWARA MASASUKE (JP)
FURUYA KENTARO (JP)
NAKAE TOMOFUMI (JP)
TANAKA KEITA (JP)
NISHINO KUNIHIKO (JP)
YAMASAKI SEIJI (JP)
NAKASHIMA RYOSUKE (JP)
SUZUKI TAKAYOSHI (JP)
TAKADA YURI (JP)
NAKAGAWA ATSUSHI (JP)
YAMASHITA EIKI (JP)
Application Number:
PCT/JP2023/030733
Publication Date:
February 29, 2024
Filing Date:
August 25, 2023
Export Citation:
Assignee:
FUJIFILM CORP (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
C07D211/34; A61K31/496; A61P31/04; C07D211/14; C07D211/22; C07D211/26; C07D211/46; C07D211/48; C07D211/58; C07D211/62; C07D211/70; C07D213/36; C07D277/28; C07D295/185; C07D305/08; C07D307/52; C07D307/79; C07D319/18; C07D333/20; C07D333/28; C07D333/32; C07D401/06; C07D401/10; C07D401/12; C07D405/06; C07D405/12; C07D409/06; C07D409/10; C07D409/12; C07D417/06; C07D417/12; C07D471/04; C07D495/04
Domestic Patent References:
| WO2020081450A1 | 2020-04-23 | |||
| WO2022047008A1 | 2022-03-03 | |||
| WO2002087589A1 | 2002-11-07 | |||
| WO2023055952A1 | 2023-04-06 |
Foreign References:
| JP2009506987A | 2009-02-19 | |||
| JP2005162726A | 2005-06-23 | |||
| CN1342649A | 2002-04-03 | |||
| CN101070308A | 2007-11-14 | |||
| JPH09241241A | 1997-09-16 | |||
| CN113527227A | 2021-10-22 | |||
| US20030229097A1 | 2003-12-11 |
Other References:
DATABASE REGISTRY 13 July 2022 (2022-07-13), ANONYMOUS : "INDEX NAME NOT YET A SSIGNED ", XP093143300, retrieved from STN Database accession no. 2790230-40-7
DATABASE REGISTRY 27 April 2012 (2012-04-27), ANONYMOUS : "Benzamide, 2-methyl-N- [1-[2-[4-[(2-methylp henyl)methyl]-1-pip erazinyl]-2- oxoethyl]-4-piperidi nyl]- (CA INDEX NAME) ", XP093143302, retrieved from STN Database accession no. 1370788-27-4
YAMASAKI SEIJI, NAKASHIMA RYOSUKE, SAKURAI KEISUKE, YAMAGUCHI AKIHITO, NISHINO KUNIHIKO: "Structural Analysis and New Drug Development against Multidrug Efflux Pumps", YAKUGAKU ZASSHI. THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 137, no. 4, 21 March 2017 (2017-03-21), pages 377 - 382, XP093143293
DATABASE REGISTRY 27 April 2012 (2012-04-27), ANONYMOUS : "Benzamide, 2-methyl-N- [1-[2-[4-[(2-methylp henyl)methyl]-1-pip erazinyl]-2- oxoethyl]-4-piperidi nyl]- (CA INDEX NAME) ", XP093143302, retrieved from STN Database accession no. 1370788-27-4
YAMASAKI SEIJI, NAKASHIMA RYOSUKE, SAKURAI KEISUKE, YAMAGUCHI AKIHITO, NISHINO KUNIHIKO: "Structural Analysis and New Drug Development against Multidrug Efflux Pumps", YAKUGAKU ZASSHI. THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 137, no. 4, 21 March 2017 (2017-03-21), pages 377 - 382, XP093143293
Attorney, Agent or Firm:
SIKS & CO. (JP)
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