Title:
NOVEL POLYPEPTIDE, DNA CODING FOR SAID POLYPEPTIDE, RECOMBINANT VECTOR CONTAINING SAID DNA, RECOMBINANT VIRUS PREPARED USING SAID VECTOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/1994/023019
Kind Code:
A1
Abstract:
A polypeptide exhibiting the antigenicity of Mycoplasma gallisepticum, a fused polypeptide comprising the above polypeptide and, connected to the N-terminus thereof, a signal membrane anchor of a type II outer-membrane polypeptide of a virus that infects birds, or a polypeptide capable of reacting with a mycoplasma-immune serum or a mycoplasma-infected serum and exhibiting a substantially pure antigenicity, respectively having amino acid sequences of about 32 kDa, about 40 kDa, or about 70kDa. The expression w ith a recombinant virus of a polypeptide modified to such an extent as to exhibit an antigenicity equivalent to that of any of the above polypeptides. The use of a recombinant virus as a live vaccine.
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Inventors:
SAITO SHUJI (JP)
OHKAWA SETSUKO (JP)
SAEKI SAKIKO (JP)
OHSAWA IKUROH (JP)
FUNATO HIRONO (JP)
IRITANI YOSHIKAZU (JP)
AOYAMA SHIGEMI (JP)
TAKAHASHI KIYOHITO (JP)
OHKAWA SETSUKO (JP)
SAEKI SAKIKO (JP)
OHSAWA IKUROH (JP)
FUNATO HIRONO (JP)
IRITANI YOSHIKAZU (JP)
AOYAMA SHIGEMI (JP)
TAKAHASHI KIYOHITO (JP)
Application Number:
PCT/JP1994/000541
Publication Date:
October 13, 1994
Filing Date:
March 31, 1994
Export Citation:
Assignee:
NIPPON ZEON CO (JP)
SHIONOGI & CO (JP)
SAITO SHUJI (JP)
OHKAWA SETSUKO (JP)
SAEKI SAKIKO (JP)
OHSAWA IKUROH (JP)
FUNATO HIRONO (JP)
IRITANI YOSHIKAZU (JP)
AOYAMA SHIGEMI (JP)
TAKAHASHI KIYOHITO (JP)
SHIONOGI & CO (JP)
SAITO SHUJI (JP)
OHKAWA SETSUKO (JP)
SAEKI SAKIKO (JP)
OHSAWA IKUROH (JP)
FUNATO HIRONO (JP)
IRITANI YOSHIKAZU (JP)
AOYAMA SHIGEMI (JP)
TAKAHASHI KIYOHITO (JP)
International Classes:
A61P31/04; C07K14/30; C12N7/01; C12N15/31; A61K39/00; (IPC1-7): C12N7/01; C12N15/31; C12N15/62; C12P21/02; C07K7/10; A61K39/02
Domestic Patent References:
| WO1993024646A1 | 1993-12-09 |
Foreign References:
| JPH01168279A | 1989-07-03 | |||
| JPH02111795A | 1990-04-24 |
Other References:
Molecular and Cellular Biology, Volume 10, No. 2, (1990), WILSON C. et al.: "Abenant Membrane Insertion of a Cytoplasmic Tail Deletion Mutant of the Hemagglutinin-Neuraminidase Glycoprotein of Newcastle Disease Virus", see p. 449-457.
See also references of EP 0692532A4
See also references of EP 0692532A4
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