Title:
NOVEL POLYPEPTIDE AND METHOD FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2007/010623
Kind Code:
A1
Abstract:
A novel polypeptide of the invention contains a peptide unit having an amino acid sequence represented by the following formula (1) and a peptide unit having an amino acid sequence represented by the following formula (2). -Pro-X-Gly- (1) -Y-Z-Gly- (2) (In the formulae, X and Z are the same or different and represent Pro or Hyp and Y represents an amino acid residue having a carboxyl group (such as Asp, Glu or Gla). The ratio (molar ratio) of the peptide unit (1) to the peptide unit (2) is around 99/1 to 1/99. On the polypeptide, an apatite may be carried. The polypeptide does not have a risk of pathogenic infection or undesired side effects and is useful in a biomaterial or biocompatible material with high safety for such as the supplement, repair or regeneration of a biological hard tissue and is also useful as a cosmetic ingredient, a food additive or the like.
Inventors:
TANIHARA MASAO (JP)
Application Number:
PCT/JP2005/013511
Publication Date:
January 25, 2007
Filing Date:
July 22, 2005
Export Citation:
Assignee:
PHG CORP (JP)
TANIHARA MASAO (JP)
TANIHARA MASAO (JP)
International Classes:
C12N15/09; A61K8/00; C07K1/10; C07K4/00; C07K14/78; C07K17/14
Domestic Patent References:
| WO2001048159A1 | 2001-07-05 | |||
| WO2001054477A2 | 2001-08-02 | |||
| WO2001064886A2 | 2001-09-07 | |||
| WO2001081401A1 | 2001-11-01 | |||
| WO2000047602A1 | 2000-08-17 | |||
| WO2000061623A1 | 2000-10-19 | |||
| WO2001044472A1 | 2001-06-21 | |||
| WO2004052910A1 | 2004-06-24 | |||
| WO2003012121A2 | 2003-02-13 | |||
| WO2003035127A1 | 2003-05-01 |
Foreign References:
| JPH022399A | 1990-01-08 | |||
| JPH07209302A | 1995-08-11 | |||
| JPH11178574A | 1999-07-06 | |||
| JPH08502071A | 1996-03-05 | |||
| JP2005194212A | 2005-07-21 | |||
| JP2005053878A | 2005-03-03 | |||
| JPH0827192A | 1996-01-30 | |||
| JPH0797454A | 1995-04-11 | |||
| JPH0853548A | 1996-02-27 | |||
| JPH07278312A | 1995-10-24 | |||
| JPH05158A | 1993-01-08 | |||
| JPH05125100A | 1993-05-21 | |||
| JPH06228506A | 1994-08-16 | |||
| JPH08276003A | 1996-10-22 | |||
| JPH0841425A | 1996-02-13 | |||
| JP2003321500A | 2003-11-11 | |||
| JPH05103829A | 1993-04-27 | |||
| JP2003190271A | 2003-07-08 | |||
| JP2003154001A | 2003-05-27 |
Other References:
MARCHANT J. ET AL.: "DNA analysis predicts a cornea-specific collaen.", PROC.NATL. ACAD.SCI. USA, vol. 88, no. 4, 1991, pages 1560 - 1564, XP000176923
BOS K. ET AL.: "rimary structure of the helical domain of porcine collaen", BIOLOGY, vol. 18, no. 2, 1999, pages 149 - 153, XP002993251
CHU L. ET AL.: "Mosaic Structure of globular domain in the human type VI collagen alpha3 chain:similarity t von Willebrand actor,fibronectin,actin,salivary proteins and aprotinin type protease inhibitors.", EMBO JOURNAL, vol. 9, no. 2, 1990, pages 385 - 393, XP000615315
SHAH K. ET AL.: "Structural Consequences of D-Amino Acids in Collagen Triple-Helical Peptides.", BIOPOLYMERS, vol. 49, no. 4, 1999, pages 297 - 302, XP002993252
METHODS ENZYMOL., vol. 82, 1982, pages 33 - 64
J. MOL. BIOL, vol. 63, 1972, pages 85 - 99
INT. J. PEPTIDE PROTEIN RES, vol. 46, 1995, pages 453 - 463
NATURE REVIEW, vol. 2, 2001, pages 118 - 126
CHEM. MATER. 15, 2003, pages 3221 - 3226
J. MOL. BIOL., vol. 63, 1972, pages 85 - 99
"Zoku Seikagaku Jikken Kouza 2, Tanpakushitsu no Kagaku (Supplemental Handbook of Biochemical Experiments, Chemistry of Protein", THE JAPANESE BIOCHEMICAL SOCIETY, 20 May 1987 (1987-05-20), pages 641 - 694
BOS K. ET AL.: "rimary structure of the helical domain of porcine collaen", BIOLOGY, vol. 18, no. 2, 1999, pages 149 - 153, XP002993251
CHU L. ET AL.: "Mosaic Structure of globular domain in the human type VI collagen alpha3 chain:similarity t von Willebrand actor,fibronectin,actin,salivary proteins and aprotinin type protease inhibitors.", EMBO JOURNAL, vol. 9, no. 2, 1990, pages 385 - 393, XP000615315
SHAH K. ET AL.: "Structural Consequences of D-Amino Acids in Collagen Triple-Helical Peptides.", BIOPOLYMERS, vol. 49, no. 4, 1999, pages 297 - 302, XP002993252
METHODS ENZYMOL., vol. 82, 1982, pages 33 - 64
J. MOL. BIOL, vol. 63, 1972, pages 85 - 99
INT. J. PEPTIDE PROTEIN RES, vol. 46, 1995, pages 453 - 463
NATURE REVIEW, vol. 2, 2001, pages 118 - 126
CHEM. MATER. 15, 2003, pages 3221 - 3226
J. MOL. BIOL., vol. 63, 1972, pages 85 - 99
"Zoku Seikagaku Jikken Kouza 2, Tanpakushitsu no Kagaku (Supplemental Handbook of Biochemical Experiments, Chemistry of Protein", THE JAPANESE BIOCHEMICAL SOCIETY, 20 May 1987 (1987-05-20), pages 641 - 694
Attorney, Agent or Firm:
KUWATA, Mitsuo (6th Floor Minato Umeda Building, 3-17, Nishitemma 6-chome, Kita-k, Osaka-shi Osaka47, JP)
Download PDF: