Title:
NOVEL PROCESS FOR PRODUCING BENZOIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1991/014673
Kind Code:
A1
Abstract:
An industrially advantageous process for producing a benzoic acid derivative of general formula (V), having a retinoid activity readily at a high yield safely. The process comprises the steps of conducting the Friedel-Crafts reaction between acetanilide, which is easily available and safely handleable, and 2,5-dimethyl-2,5-dichlorohexane, conducting acyl interchange between the reaction product and monomethyl ester chloride of terephthalic acid, hydrolyzing the reaction product, and recrystallizing the hydrolyzate from methanol/water, wherein these various steps of reaction are conduct in one and the same vessel. The crystals of the obtained compound are suitable for pharmaceutical preparation because they contain a reduced amount of a residual recrystallization solvent and have uniform particle sizes.
Inventors:
HAMADA YOSHINORI (JP)
YAMADA ISAMU (JP)
UENAKA MASAAKI (JP)
SAKATA TERUO (JP)
YAMADA ISAMU (JP)
UENAKA MASAAKI (JP)
SAKATA TERUO (JP)
Application Number:
PCT/JP1991/000350
Publication Date:
October 03, 1991
Filing Date:
March 15, 1991
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
A61K9/127; A61K31/165; A61K31/196; A61P3/00; A61K31/00; C07C231/12; C07C231/14; C07C231/24; C07C233/04; C07C233/07; C07C233/11; C07C233/65; C07C235/84; (IPC1-7): C07C231/12; C07C231/14; C07C233/07; C07C233/65
Foreign References:
| JPS6176440A | 1986-04-18 | |||
| JPS63130569A | 1988-06-02 |
Other References:
See also references of EP 0478787A1
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