NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3)

Title:

NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3)

Document Type and Number:

WIPO Patent Application WO/2007/023768

Kind Code:

A1

Abstract:

A compound represented by the general formula: (I) (wherein R1 means a 3- to 10-membered nonaromatic heterocyclic group or the like; R2 and R3 mean a hydrogen atom; R4, R5, R6 and R7 are the same or different and mean a hydrogen atom, a halogen atom, a C1-6 alkyl group or the like; R8 means a hydrogen atom or the like; R9 means a 3- to 10-membered nonaromatic heterocyclic group or the like; n means an integer of 1 to 2; and X means a group represented by the formula -CH= or a nitrogen atom), a salt thereof or a hydrate thereof has an excellent hepatocyte growth factor receptor (HGFR) inhibitory action, and exhibits an anti-tumor action, angiogenesis inhibitory action or cancer metastasis inhibitory action.

Inventors:

MATSUSHIMA TOMOHIRO (JP)
TAKAHASHI KEIKO (JP)
FUNASAKA SETSUO (JP)
OBAISHI HIROSHI (JP)
SHIROTORI SHUJI (JP)

Application Number:

PCT/JP2006/316331

Publication Date:

March 01, 2007

Filing Date:

August 21, 2006

Export Citation:

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Assignee:

EISAI R&D MAN CO LTD (JP)
MATSUSHIMA TOMOHIRO (JP)
TAKAHASHI KEIKO (JP)
FUNASAKA SETSUO (JP)
OBAISHI HIROSHI (JP)
SHIROTORI SHUJI (JP)

International Classes:

C07D213/75; A61K31/4409; A61K31/496; A61K31/506; A61K31/5377; A61P35/00; A61P35/04; A61P43/00; C07D239/47; C07D401/12

Domestic Patent References:

WO2002032872A1	2002-04-25
WO2004089286A2	2004-10-21
WO2003000660A1	2003-01-03
WO2004076412A2	2004-09-10
WO2005082855A1	2005-09-09
WO2005082854A1	2005-09-09

Other References: