NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF

Title:

NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF

Document Type and Number:

WIPO Patent Application WO/2017/217441

Kind Code:

A1

Abstract:

Provided are a novel pyridonecarboxylic acid derivative which is highly effective even against bacteria such as methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Clostridium difficile, and is less likely to be affected by a drug efflux pump, or a salt thereof, and an antibacterial agent containing the pyridonecarboxylic acid derivative or a salt thereof. The pyridonecarboxylic acid derivative is represented by formula (1): (in the formula, R1 represents a hydrogen atom, a halogen atom, a lower alkyl group, or an amino group; R2 represents radical-NH-R6 (here, R6 represents a hydrogen atom, a lower alkyl group, an amino lower alkyl group, etc.), radical-O-R7 (here, R7 represents a hydrogen atom, a lower alkyl group, etc.), radical-(CH2)m-R8 (here, R8 represents an amino group, etc., m represents an integer of 1-4), or a cyclic amino group represented by formula (2): (in the formula, Y represents NH or C-R9aR9b (here, R9a and R9b each independently represent a hydrogen atom, a lower alkyl group, an amino group, a lower alkylamino group, etc.), and n and p are an integer of 1 or 2); R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, etc.; R4 represents a hydrogen atom or a carboxyl group-protecting group; R5 represents a hydrogen atom or a hydroxy group-protecting group). Alternatively, a salt thereof is provided.

Inventors:

KINOSHITA TOMOHIKO (JP)
KURAMOTO YASUHIRO (JP)
INOUE SATOSHI (JP)
NISHIMURA KOUJI (JP)
HIRANO TATSUYA (JP)
ARAI MAI (JP)
SAKURAI ASUKA (JP)
KAZAMORI DAICHI (JP)
SASAKI AYUKA (JP)

Application Number:

PCT/JP2017/021899

Publication Date:

December 21, 2017

Filing Date:

June 14, 2017

Export Citation:

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Assignee:

WAKUNAGA PHARMA CO LTD (JP)

International Classes:

C07D215/56; A61K31/47; A61K31/4709; A61K31/496; A61K31/5377; A61P31/04; C07D401/04; C07D401/14; C07D405/14

Domestic Patent References:

WO1996023775A1	1996-08-08
WO1997040036A1	1997-10-30

Foreign References:

JPS6056959A	1985-04-02
US4762845A	1988-08-09
JPH037260A	1991-01-14

Other References: