NOVEL PYRIMIDINE DERIVATIVE AND MEDICINAL COMPOSITION

Title:

NOVEL PYRIMIDINE DERIVATIVE AND MEDICINAL COMPOSITION

Document Type and Number:

WIPO Patent Application WO/1995/016677

Kind Code:

A1

Abstract:

A pyrimidine derivative represented by general formula (I) or a salt thereof, having an angiotensin II antagonism. In said formula, A represents (I-1) or (I-2), R1 and R2 represent each independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, acetyl, halogen, phenyl or substituted phenyl; R3 represents hydrogen, alkyl, alkenyl, alkynyl or acetyl; X represents O, MH or S(O)p; p represents an integer of 0 to 2; m represents an integer of 1 or 2; B represents carboxy, alkoxycarbonyl, cyano, tetrazolyl or protected tetrazolyl; and n represents an integer of 1 to 2.

Inventors:

OHKUBO AKIHIRO (JP)
MINEGISHI TORATARO (JP)
MIZUTA TADASHI (JP)
SATO HIROAKI (JP)
YAMADA MASASHI (JP)
YABUTA TOMOKO (JP)

Application Number:

PCT/JP1994/002114

Publication Date:

June 22, 1995

Filing Date:

December 16, 1994

Export Citation:

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Assignee:

NIPPON KOKAN KK (JP)
OHKUBO AKIHIRO (JP)
MINEGISHI TORATARO (JP)
MIZUTA TADASHI (JP)
SATO HIROAKI (JP)
YAMADA MASASHI (JP)
YABUTA TOMOKO (JP)

International Classes:

C07D239/34; C07D239/36; C07D403/10; C07D403/12; (IPC1-7): C07D239/34; A61K31/505; C07D239/36; C07D239/38; C07D239/40; C07D239/42; C07D403/12

Foreign References:

US5087634A	1992-02-11
EP0445811A2	1991-09-11

Other References: