Title:
NOVEL PYRIMIDINE OR TRIAZINE-SUBSTITUTED PYRIDOHETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2024/008048
Kind Code:
A1
Abstract:
Disclosed is a novel substituted pyrimidoheterocyclic compound, which can be used as an EGFR mutation target inhibitor. Specifically disclosed are a compound represented by the structure in formula (I) or pharmaceutically acceptable salts, solvates, hydrates, isotope substitutions or isomers thereof. The compound has an affinity effect on EGFR mutation targets, and especially has a strong inhibitory effect on the activity of mutant proteins such as EGFR19Del-T790M-C797S, EGFRL858R-T790M-C797S, EGFR19Del-C797S, EGFRL858R-C797S, EGFR-C797S, etc. The compound can be used to prepare drugs or molecular probes for preventing or treating diseases related to EGFR mutation signaling pathways (such as cancer, immune diseases, etc.).
Inventors:
ZHANG LONG (CN)
NIU ZHANGMING (CN)
NIU ZHANGMING (CN)
Application Number:
PCT/CN2023/105583
Publication Date:
January 11, 2024
Filing Date:
July 03, 2023
Export Citation:
Assignee:
MINDRANK AI LTD (CN)
International Classes:
C07D401/14; A61K31/506; A61P35/00; C07D471/04
Domestic Patent References:
| WO2023134266A1 | 2023-07-20 | |||
| WO2022271612A1 | 2022-12-29 | |||
| WO2023071998A1 | 2023-05-04 | |||
| WO2023025320A1 | 2023-03-02 | |||
| WO2022271630A1 | 2022-12-29 | |||
| WO2023070114A2 | 2023-04-27 | |||
| WO2021133809A1 | 2021-07-01 | |||
| WO2016070816A1 | 2016-05-12 | |||
| WO2014210354A1 | 2014-12-31 |
Foreign References:
| CN116554150A | 2023-08-08 | |||
| CN115650958A | 2023-01-31 | |||
| CN116262741A | 2023-06-16 |
Other References:
MEREDITH, S. E. ET AL.: "Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer", J. MED. CHEM., vol. 65, no. 14, 15 July 2022 (2022-07-15), XP055959499, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.2c00704
BRYAN, K. C. ET AL.: "Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor", J. MED. CHEM., vol. 59, no. 19, 26 August 2016 (2016-08-26), XP055497250, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00995
BRYAN, K. C. ET AL.: "Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor", J. MED. CHEM., vol. 59, no. 19, 26 August 2016 (2016-08-26), XP055497250, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00995
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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