Title:
NOVEL PYRROLE DERIVATIVE HAVING, AS SUBSTITUENTS, UREIDE GROUP, AMINOCARBONYL GROUP AND BICYCLIC GROUP WHICH MAY HAVE SUBSTITUENT
Document Type and Number:
WIPO Patent Application WO/2010/024227
Kind Code:
A1
Abstract:
Disclosed is a novel pyrrole derivative having, as substituents, a ureide group, an aminocarbonyl group and a bicyclic group which may have a substituent, or a salt of the derivative. A compound represented by general formula (1) or a salt thereof has an inhibitory activity on the production of interleukin-6, and is therefore useful as a prophylactic or therapeutic agent for diseases associated with interleukin-6, inflammatory ophthalmic diseases and the like. In the formula, R1 represents a halogen atom, a hydrogen atom, a lower alkyl group which may have a substituent, a formyl group, or a lower alkylcarbonyl group which may have a substituent; R2 represents a bicyclic hydrocarbon group which may have a substituent, or a bicyclic hetero ring group which may have a substituent; and R3 represents a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, or an acyl group.
Inventors:
KAWASHIMA KENJI (JP)
KAWASHIMA NORIKO (JP)
ENOMOTO HIROSHI (JP)
YAMAMOTO MINORU (JP)
MURAI MASAAKI (JP)
KAWASHIMA NORIKO (JP)
ENOMOTO HIROSHI (JP)
YAMAMOTO MINORU (JP)
MURAI MASAAKI (JP)
Application Number:
PCT/JP2009/064744
Publication Date:
March 04, 2010
Filing Date:
August 25, 2009
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
KAWASHIMA KENJI (JP)
KAWASHIMA NORIKO (JP)
ENOMOTO HIROSHI (JP)
YAMAMOTO MINORU (JP)
MURAI MASAAKI (JP)
KAWASHIMA KENJI (JP)
KAWASHIMA NORIKO (JP)
ENOMOTO HIROSHI (JP)
YAMAMOTO MINORU (JP)
MURAI MASAAKI (JP)
International Classes:
C07D207/34; A61K31/40; A61K31/4025; A61K31/404; A61K31/428; A61K31/538; A61K31/5415; A61P27/02; A61P43/00; C07D403/04; C07D405/04; C07D409/04; C07D413/04; C07D417/04
Domestic Patent References:
| WO2008087933A1 | 2008-07-24 | |||
| WO2008105408A1 | 2008-09-04 | |||
| WO2003086371A2 | 2003-10-23 | |||
| WO2005123671A1 | 2005-12-29 |
Foreign References:
| JP2003522766A | 2003-07-29 | |||
| JP2004536869A | 2004-12-09 |
Other References:
PODOLIN, P.L. ET AL.: "Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IKB kinase 2, TPCA-1(2-[(aminocarbonyl)amino]-5- (4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 312, no. 1, 2005, pages 373 - 381, XP002631348
BESSATSU IGAKU NO AYUMI, JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, SUPPLEMENT
KISO KARA RINSHO OYO, CYTOKINES, 1992, pages 28 - 35
"E-Abstract", INVEST. OPHTHALMOL. VIS. SCI., vol. 47, 2006, pages 905
DIABETES. RES. CLIN. PRACT., vol. 61, 2003, pages 93 - 101
OPHTHALMOLOGY, vol. 110, 2003, pages 1690 - 1696
DATABASE REGISTER STN; accession no. 75823-41-9
J. CHEM. SOC. PERKIN TRANSACTIONS, vol. 1, no. 5, 1978, pages 483 - 497
See also references of EP 2319831A4
BESSATSU IGAKU NO AYUMI, JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, SUPPLEMENT
KISO KARA RINSHO OYO, CYTOKINES, 1992, pages 28 - 35
"E-Abstract", INVEST. OPHTHALMOL. VIS. SCI., vol. 47, 2006, pages 905
DIABETES. RES. CLIN. PRACT., vol. 61, 2003, pages 93 - 101
OPHTHALMOLOGY, vol. 110, 2003, pages 1690 - 1696
DATABASE REGISTER STN; accession no. 75823-41-9
J. CHEM. SOC. PERKIN TRANSACTIONS, vol. 1, no. 5, 1978, pages 483 - 497
See also references of EP 2319831A4
Attorney, Agent or Firm:
HIBI, Norihiko et al. (JP)
Norihiko Hibi (JP)
Norihiko Hibi (JP)
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