NOVEL PYRROLINONE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING SAME

WIPO Patent Application WO/2010/035727

A1

Provided are novel P2X3 and/or P2X2/3 receptor antagonists. A compound represented by formula (I) [wherein Z1 represents optionally protected hydroxy or the like; Z2 represents -C(=O)- or the like; Z3a and Z3b form together =O, =S or the like; t is an integer of 0 to 4; R4a and R4b independently represent each hydrogen, substituted or unsubstituted lower alkyl or the like; m and n independently represent each an integer of 0 to 2; k is an integer of 0 or 1; ring A is an aromatic carbon ring, a hetero ring or the like; B is aromatic carbon ring-diyl, hetero ring-diyl or the like; R1a and R1b independently represent each halogen, hydroxy, substituted or unsubstituted lower alkyl or the like; R2 represents substituted or unsubstituted alkyl or the like; and R3 represents substituted or unsubstituted alkyl, substituted or unsubstituted aryl, a substituted or unsubstituted heterocyclic group or the like], a pharmaceutically acceptable salt thereof or a solvate of the same.

KAI HIROYUKI (JP)
TAODA YOSHIYUKI (JP)
ENDOH TAKESHI (JP)
HORIGUCHI TOHRU (JP)
ASAHI KENTARO (JP)
TOBINAGA HIROYUKI (JP)

PCT/JP2009/066473

April 01, 2010

September 24, 2009

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SHIONOGI & CO (JP)
KAI HIROYUKI (JP)
TAODA YOSHIYUKI (JP)
ENDOH TAKESHI (JP)
HORIGUCHI TOHRU (JP)
ASAHI KENTARO (JP)
TOBINAGA HIROYUKI (JP)

C07D207/38; A61K31/402; A61K31/4025; A61K31/404; A61K31/4162; A61K31/422; A61K31/4245; A61K31/427; A61K31/428; A61K31/4439; A61K31/444; A61P7/10; A61P7/12; A61P13/08; A61P13/10; A61P25/04; A61P29/00; A61P43/00; C07D401/04; C07D401/10; C07D403/04; C07D405/14; C07D409/10; C07D409/14; C07D413/10; C07D413/14; C07D417/04; C07D487/04

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TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)

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