Title:
NOVEL PYRROLOPYRIMIDINONE CARBOXAMIDE COMPOUND FOR INHIBITING CDK, STEREOISOMER THEREOF OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER, COMPRISING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/219427
Kind Code:
A1
Abstract:
The present invention relates to a pyrrolopyrimidinone carboxamide compound represented by chemical formula 1, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for treating cancer, comprising same as an active ingredient. Specifically, the compound increases plasma stability so that, until cancer cells are reached, the structure thereof is maintained, and thus exhibits anticancer effects greater than those of a conventional compound.
Inventors:
KIM BYEONG MOON (KR)
JEONG SEONG YUN (KR)
CHOI EUN-KYUNG (KR)
PARK SEOK SOON (KR)
KWON MI RI (KR)
PARK JI SU (KR)
JEONG SEONG YUN (KR)
CHOI EUN-KYUNG (KR)
PARK SEOK SOON (KR)
KWON MI RI (KR)
PARK JI SU (KR)
Application Number:
PCT/KR2023/006372
Publication Date:
November 16, 2023
Filing Date:
May 10, 2023
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
C07H19/14; A61K31/7064; A61P35/00; C07H1/00
Domestic Patent References:
| WO2012060482A1 | 2012-05-10 |
Foreign References:
| KR20120046506A | 2012-05-10 | |||
| JP2004529979A | 2004-09-30 |
Other References:
PARK SEOK SOON, KIM YOUNG-JONG, JU EUN JIN, SHIN SEOL HWA, CHOI JINHYANG, PARK JAESOOK, LEE JAE HEE, LEE KYOUNG JIN, PARK JIN, PAR: "Ibulocydine sensitizes human cancers to radiotherapy by induction of mitochondria-mediated apoptosis", RADIOTHERAPY AND ONCOLOGY, ELSEVIER, IRELAND, vol. 112, no. 2, 1 August 2014 (2014-08-01), Ireland , pages 295 - 301, XP093106872, ISSN: 0167-8140, DOI: 10.1016/j.radonc.2014.07.005
SEUNG-JU CHO, YOUNG-JONG KIM, YOUNG-JOON SURH, B. MOON KIM, SEUNG-KI LEE: "Ibulocydine Is a Novel Prodrug Cdk Inhibitor That Effectively Induces Apoptosis in Hepatocellular Carcinoma Cells", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 286, no. 22, 3 June 2011 (2011-06-03), US , pages 19662 - 19671, XP055403139, ISSN: 0021-9258, DOI: 10.1074/jbc.M110.209551
SEUNG-JU CHO, YOUNG-JONG KIM, YOUNG-JOON SURH, B. MOON KIM, SEUNG-KI LEE: "Ibulocydine Is a Novel Prodrug Cdk Inhibitor That Effectively Induces Apoptosis in Hepatocellular Carcinoma Cells", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 286, no. 22, 3 June 2011 (2011-06-03), US , pages 19662 - 19671, XP055403139, ISSN: 0021-9258, DOI: 10.1074/jbc.M110.209551
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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