Title:
NOVEL QUINOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND ANTIVIRAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2020/080682
Kind Code:
A1
Abstract:
The present invention relates to a novel quinolinone derivative, a preparation method therefor, and an antiviral composition containing same as an active ingredient. A novel quinolinone derivative provided in one aspect of the present invention exhibits an excellent inhibitory activity against a coronavirus infection, and thus can be effectively used as a pharmaceutical composition for preventing or treating a disease caused by a coronavirus infection, that is, MERS.
Inventors:
KIM HYOUNG RAE (KR)
PARK CHUL MIN (KR)
SONG JONG HWAN (KR)
KIM SEUNGTAEK (KR)
LEE JIHYE (KR)
CHANG SO YOUNG (KR)
MIN JI-YOUNG (KR)
KWON SUN OH (KR)
JIN YOUNG-HEE (KR)
KIM GEON-WOO (KR)
KIM DONG EON (KR)
JANG MIN SEONG (KR)
PARK CHUL MIN (KR)
SONG JONG HWAN (KR)
KIM SEUNGTAEK (KR)
LEE JIHYE (KR)
CHANG SO YOUNG (KR)
MIN JI-YOUNG (KR)
KWON SUN OH (KR)
JIN YOUNG-HEE (KR)
KIM GEON-WOO (KR)
KIM DONG EON (KR)
JANG MIN SEONG (KR)
Application Number:
PCT/KR2019/011856
Publication Date:
April 23, 2020
Filing Date:
September 11, 2019
Export Citation:
Assignee:
KOREA RES INST CHEMICAL TECH (KR)
PASTEUR INSTITUT KOREA (KR)
KOREA INST ORIENTAL MEDICINE (KR)
PASTEUR INSTITUT KOREA (KR)
KOREA INST ORIENTAL MEDICINE (KR)
International Classes:
C07D215/233; A23L29/00; A23L33/10; A61K31/47; A61P31/14
Foreign References:
| KR101882790B1 | 2018-08-24 | |||
| KR20180044185A | 2018-05-02 | |||
| KR20150083353A | 2015-07-17 | |||
| KR20080077889A | 2008-08-26 |
Other References:
SHARMA, M. C. ET AL.: "Molecular modeling studies of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4- one derivatives as phosphatase SerB653 inhibitors", MED. CHEM. RES., vol. 25, 2016, pages 2119 - 2126, XP036081682, DOI: 10.1007/s00044-016-1624-9
KANG, D. -H. ET AL.: "Identification of 3-Acetyl-2-aminoquinolin-4-one as a Hovel, Nonpeptidic Scaffold for Specific Calpain Inhibitory Activity", J. MED. CHEM., vol. 52, no. 9, 2009, pages 3093 - 3097, XP055703752, DOI: 10.1021/jm8014734
XU, K. ET AL.: "Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 154, 19 May 2018 (2018-05-19), pages 144 - 1 54, XP055703753, DOI: 10.1016/j.ejmech.2018.05.021
KANG, D. -H. ET AL.: "Identification of 3-Acetyl-2-aminoquinolin-4-one as a Hovel, Nonpeptidic Scaffold for Specific Calpain Inhibitory Activity", J. MED. CHEM., vol. 52, no. 9, 2009, pages 3093 - 3097, XP055703752, DOI: 10.1021/jm8014734
XU, K. ET AL.: "Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 154, 19 May 2018 (2018-05-19), pages 144 - 1 54, XP055703753, DOI: 10.1016/j.ejmech.2018.05.021
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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