Title:
NOVEL RIBOSE-SUBSTITUTED AROMATIC AMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS
Document Type and Number:
WIPO Patent Application WO2000063222
Kind Code:
A3
Abstract:
Compounds of formula (I); wherein R1 = alkyl, alkenyl or alkynyl, O-alkyl, O-alkenyl or optionally substituted, optionally interrupted O-alkynyl; R2 = hydrogen or halogen; R3 = hydrogen, alkyl or halogen; R4= NHR' or NHOR'', R' or R'' are identical or different and represent hydrogen, alkyl, alkenyl or alkynyl, aryl; R5= hydrogen or O-alkyl; R6= alkyl or CH2-O-alkyl; R7= hydrogen or alkyl or R6 et R7 form a cycle together with the carbon carrying them in addition to the addition salts thereof with bases. The compounds of formula (I) have antibiotic properties.
Inventors:
DEMASSEY JACQUES (FR)
KLICH MICHEL (FR)
MUSICKI BRANISLAV (FR)
KLICH MICHEL (FR)
MUSICKI BRANISLAV (FR)
Application Number:
PCT/FR2000/000999
Publication Date:
May 31, 2001
Filing Date:
April 18, 2000
Export Citation:
Assignee:
AVENTIS PHARMA SA (FR)
DEMASSEY JACQUES (FR)
KLICH MICHEL (FR)
MUSICKI BRANISLAV (FR)
DEMASSEY JACQUES (FR)
KLICH MICHEL (FR)
MUSICKI BRANISLAV (FR)
International Classes:
A61K31/7048; A61P9/10; A61P27/16; A61P31/04; A61P31/16; C07H17/075; (IPC1-7): C07H17/075; A61K31/70; A61P31/04
Foreign References:
| US3890297A | 1975-06-17 | |||
| FR2052923A1 | 1971-04-16 |
Other References:
BELL, WILLIAM ET AL: "Design, synthesis and evaluation of a novel series of spiroketals based o the structure of the antibacterial gyrase inhibitor novobiocin", J. CHEM. SOC., PERKIN TRANS. 1 (1997), (18), 2789-2801, XP002127248
CROW, FRANK W. ET AL: "Complete spectroscopic structural characterization of novobiocin, isonovobiocin, decarbamylnovobiocin, 2''-(O-Carbamyl)novobiocin, and novobiocin-2'',3''-carbonate", J. HETEROCYCL. CHEM. (1999), 36(2), 365-370, XP002127249
CROW, FRANK W. ET AL: "Complete spectroscopic structural characterization of novobiocin, isonovobiocin, decarbamylnovobiocin, 2''-(O-Carbamyl)novobiocin, and novobiocin-2'',3''-carbonate", J. HETEROCYCL. CHEM. (1999), 36(2), 365-370, XP002127249
Download PDF: