Title:
NOVEL SERINE PROTEASE BSSP5
Document Type and Number:
WIPO Patent Application WO/2000/031243
Kind Code:
A1
Abstract:
Proteins having the amino acid sequences represented by SEQ ID NOS: 2 and 4; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and base sequences encoding the same. Transgenic non-human animals with altered expression level of a serine protease BSSP5; an antibody against BSSP5; and a method for detecting BSSP5 in a specimen by using the antibody. The BSSP5 thus provided is useable in treating and diagnosing various diseases such as Alzheimer's disease (AD), epilepsy, cancer, inflammation, sterility and prostatic hypertrophy and detecting pancreatitis in various tissues including brain, prostate gland, placenta, testis, pancreas and spleen.
Inventors:
UEMURA HIDETOSHI (JP)
OKUI AKIRA (JP)
KOMINAMI KATSUYA (JP)
YAMAGUCHI NOZOMI (JP)
MITSUI SHINICHI (JP)
OKUI AKIRA (JP)
KOMINAMI KATSUYA (JP)
YAMAGUCHI NOZOMI (JP)
MITSUI SHINICHI (JP)
Application Number:
PCT/JP1999/006473
Publication Date:
June 02, 2000
Filing Date:
November 19, 1999
Export Citation:
Assignee:
FUSO PHARMACEUTICAL IND (JP)
UEMURA HIDETOSHI (JP)
OKUI AKIRA (JP)
KOMINAMI KATSUYA (JP)
YAMAGUCHI NOZOMI (JP)
MITSUI SHINICHI (JP)
UEMURA HIDETOSHI (JP)
OKUI AKIRA (JP)
KOMINAMI KATSUYA (JP)
YAMAGUCHI NOZOMI (JP)
MITSUI SHINICHI (JP)
International Classes:
C12N1/21; C12N9/64; C12N15/57; C12P21/08; G01N33/573; A61K38/00; (IPC1-7): C12N9/50; C12N15/57; C12N1/21; A01K67/027; C07K16/40; C12P21/08; G01N33/53
Domestic Patent References:
| WO1997024135A1 | 1997-07-10 |
Foreign References:
| US5731439A | 1998-03-24 | |||
| JPH09149790A | 1997-06-10 | |||
| JPH06181767A | 1994-07-05 |
Other References:
LARSEN F. ET AL.: "A tight cluster of five unrelated human genes on chromosome 16q22.1", HUMAN MOLECULAR GENETICS,, vol. 2, no. 10, 1993, pages 1589 - 1595, XP002924301
YAMAMURA Y. ET AL.: "Molecular cloning of a novel brain-specific serine protease with a kringle-like structure and three scavenger receptor cysteine-rich motifs", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,, vol. 239, 1997, pages 386 - 392, XP002924302
YAMANURA, Y ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 239, 1997, pages 386
GSCHWEND, T. P. ET AL., MOL. CELL. NEUROSCI., vol. 9, 1997, pages 207
CHEN, Z-L ET AL., J. NEUROSCI., vol. 15, 1995, pages 5088
BIOCHIMICA ET BYOPHYSICA ACTA, vol. 1350, 1997, pages 11 - 14
RESELAND, J. BIOL. CHEM, vol. 272, 1997, pages 8099
CHIRWIN ET AL., BIOCHEMISTRY, vol. 18, 1979, pages 5294
MATTENCCI, M. D. ET AL., J. AM. CHEM. SOC., vol. 130, 1981, pages 3185
GRANTHAM, R. ET AL., NUCLEIC ACIDS RES., vol. 9, 1989, pages R43
MARK, D. F. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 81, 1984, pages 5662
J. IMMUNOL., vol. 155, 1995, pages 2477
PROC. NATL. ACAD. SCI., USA, vol. 92, 1995, pages 3561
KOEHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495
J. IMMUNOL. METHOD, vol. 39, 1980, pages 285
EUR. J. BIOCHEM, vol. 118, 1981, pages 437
NATURE, vol. 285, 1980, pages 446
J. IMMUNOL. METH., vol. 53, 1982, pages 313
"National Institute of Bioscience and Human-Technology", AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY, 29 October 1998 (1998-10-29)
BIOCHIM. BIOPHYS. ACTA, vol. 1350, 1997, pages 11
See also references of EP 1142993A4
YAMAMURA Y. ET AL.: "Molecular cloning of a novel brain-specific serine protease with a kringle-like structure and three scavenger receptor cysteine-rich motifs", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,, vol. 239, 1997, pages 386 - 392, XP002924302
YAMANURA, Y ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 239, 1997, pages 386
GSCHWEND, T. P. ET AL., MOL. CELL. NEUROSCI., vol. 9, 1997, pages 207
CHEN, Z-L ET AL., J. NEUROSCI., vol. 15, 1995, pages 5088
BIOCHIMICA ET BYOPHYSICA ACTA, vol. 1350, 1997, pages 11 - 14
RESELAND, J. BIOL. CHEM, vol. 272, 1997, pages 8099
CHIRWIN ET AL., BIOCHEMISTRY, vol. 18, 1979, pages 5294
MATTENCCI, M. D. ET AL., J. AM. CHEM. SOC., vol. 130, 1981, pages 3185
GRANTHAM, R. ET AL., NUCLEIC ACIDS RES., vol. 9, 1989, pages R43
MARK, D. F. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 81, 1984, pages 5662
J. IMMUNOL., vol. 155, 1995, pages 2477
PROC. NATL. ACAD. SCI., USA, vol. 92, 1995, pages 3561
KOEHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495
J. IMMUNOL. METHOD, vol. 39, 1980, pages 285
EUR. J. BIOCHEM, vol. 118, 1981, pages 437
NATURE, vol. 285, 1980, pages 446
J. IMMUNOL. METH., vol. 53, 1982, pages 313
"National Institute of Bioscience and Human-Technology", AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY, 29 October 1998 (1998-10-29)
BIOCHIM. BIOPHYS. ACTA, vol. 1350, 1997, pages 11
See also references of EP 1142993A4
Attorney, Agent or Firm:
Aoyama, Tamotsu (Shiromi 1-chome Chuo-ku, Osaka-shi Osaka, JP)
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