Title:
NOVEL SPIRO COMPOUND AND APPLICATION THEREOF IN DRUG
Document Type and Number:
WIPO Patent Application WO/2021/197486
Kind Code:
A1
Abstract:
A novel spiro compound and an application thereof in a drug, in particular, use thereof as a drug for treating and/or preventing hepatitis B. Specifically, the present invention relates to a compound represented by formula (I) or a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, and use of the compounds as a drug, in particular, the use as a drug for treating and preventing hepatitis B, wherein variables are defined in the description.
Inventors:
REN QINGYUN (CN)
LI ZHONGLE (CN)
JI SHILONG (CN)
ZHANG YINGJUN (CN)
LI ZHONGLE (CN)
JI SHILONG (CN)
ZHANG YINGJUN (CN)
Application Number:
PCT/CN2021/085352
Publication Date:
October 07, 2021
Filing Date:
April 02, 2021
Export Citation:
Assignee:
DONGGUAN HEC NEW DRUG R&D CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
A61K31/4025; C07D207/34; A61P31/20; C07D413/12; C07D413/14
Domestic Patent References:
| WO2017136403A1 | 2017-08-10 | |||
| WO2019241292A1 | 2019-12-19 | |||
| WO2019185016A1 | 2019-10-03 | |||
| WO2019154343A1 | 2019-08-15 |
Foreign References:
| CN109153640A | 2019-01-04 | |||
| CN104812743A | 2015-07-29 | |||
| CN108250121A | 2018-07-06 | |||
| CN109790168A | 2019-05-21 |
Other References:
LV KAI; WU SHUO; LI WENYAN; GENG YUNHE; WU MENG; ZHOU JINMING; LI YUHUAN; GAO QIANG; LIU MINGLIANG: "Design, Synthesis and Anti-HBV Activity of NVR3-778 Derivatives.", BIOORGANIC CHEMISTRY, vol. 94, 14 October 2019 (2019-10-14), pages 1 - 5, XP085989037, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2019.103363
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