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Title:
NOVEL SUBSTITUTED BENZIMIDAZOLE, METHODS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING SAME, AND USE THEREOF TO PRODUCE MEDICAMENTS
Document Type and Number:
WIPO Patent Application WO/2017/207340
Kind Code:
A1
Abstract:
The invention relates to novel substituted benzimidazoles, to methods for the production thereof, to the use thereof alone or in combinations to treat and/or prevent diseases, and to the use thereof to produce medicaments for treating and/or preventing diseases, in particular for treating and/or preventing endometriosis and endometriosis-associated pain and other symptoms associated with endometriosis such as dysmenorrhea, dyspareunia, dysuria, and dyschezia, lymphomas, rheumatoid arthritis, spondyloarthritides (in particular psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver diseases, insulin resistance, tumor diseases, kidney diseases and psoriasis.

Inventors:
RING SVEN (DE)
BOTHE ULRICH (DE)
NUBBEMEYER REINHARD (DE)
BÖMER ULF (DE)
GÜNTHER JUDITH (DE)
SCHMIDT NICOLE (US)
ANDRES DOROTHEE (DE)
SIEBENEICHER HOLGER (DE)
Application Number:
PCT/EP2017/062367
Publication Date:
December 07, 2017
Filing Date:
May 23, 2017
Export Citation:
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Assignee:
BAYER PHARMA AG (DE)
International Classes:
C07D403/12; A61K31/4439; A61P29/00; A61P37/00; C07D401/12; C07D401/14; C07D403/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14
Domestic Patent References:
WO2015091426A12015-06-25
WO2015091426A12015-06-25
WO2003030902A12003-04-17
WO2013042137A12013-03-28
WO2006030031A12006-03-23
WO2004072069A12004-08-26
WO1994022839A11994-10-13
WO2001057020A12001-08-09
WO2010042785A12010-04-15
WO2013186229A12013-12-19
WO2007076092A22007-07-05
WO2012112743A12012-08-23
WO2005082866A22005-09-09
WO2006061715A22006-06-15
WO2012061926A12012-05-18
WO2009117421A22009-09-24
WO2012107475A12012-08-16
WO2007048070A22007-04-26
WO2008128009A22008-10-23
Foreign References:
EP1553089A12005-07-13
DE3486121T21993-07-15
US20070185058A12007-08-09
US20030236260A12003-12-25
Other References:
JANEWAY; MEDZHITOV, ANNU. REV. IMMUNOL., 2002
DINARELLO, ANNU. REV. IMMUNOL., 2009
FLANNERY; BOWIE, BIOCHEMICAL PHARMACOLOGY, 2010
SUZUKI, SUZUKI ET AL., NATURE, 2002
DAVIDSON, CURRIE ET AL., THE JOURNAL OF IMMUNOLOGY, 2006
KU, VON BERNUTH ET AL., JEM, 2007
KIM, STASCHKE ET AL., JEM, 2007
KOLLEWE, MACKENSEN ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, 2004
PRECIOUS ET AL., J. BIOL. CHEM., 2009
WANG, DENG ET AL., NATURE, 2001
HOLTMANN, ENNINGA ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, 2001
DATTA, NOVOTNY ET AL., JOURNAL OF IMMUNOLOGY, 2004
WAN, CHI ET AL., NAT IMMUNOL, 2006
MCGETTRICK; J. O'NEILL, BRITISH JOURNAL OF HAEMATOLOGY, 2007
REKHTER, STASCHKE ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATION, 2008
MAEKAWA, MIZUE ET AL., CIRCULATION, 2009
STASCHKE, DONG ET AL., THE JOURNAL OF IMMUNOLOGY, 2009
KIM, FEBBRAIO ET AL., THE JOURNAL OF IMMUNOLOGY, 2011
CAMERON, TSE ET AL., THE JOURNAL OF NEUROSCIENCE, 2012
VALAPERTI, NISHII ET AL., CIRCULATION, 2013
SUN, YANG ET AL., PLOS ONE, 2014
CHIANG ET AL., THE JOURNAL OF IMMUNOLOGY, 2010
AHMAD, R., P. SHIHAB ET AL., DIABETOLOGY & METABOLIC SYNDROME, 2015
STASCHKE ET AL., THE JOURNAL OF IMMUNOLOGY, 2009
MARQUEZ ET AL., ANN RHEUM DIS, 2014
ZAMBRANO-ZARAGOZA ET AL., INTERNATIONAL JOURNAL OF INFLAMMATION, 2014
WANG ET AL., EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2015
CICCIA ET AL., RHEUMATOLOGY, 2015
YANG, TUZUN ET AL., J IMMUNOL, 2005
CANDIA, MARQUEZ ET AL., THE JOURNAL OF RHEUMATOLOGY, 2007
SCANZELLO, PLAAS ET AL., CURR OPIN RHEUMATOL, 2008
DENG, MA-KRUPA ET AL., CIRC RES, 2009
ROGER, FROIDEVAUX ET AL., PNAS, 2009
DEVARAJ, TOBIAS ET AL., ARTERIOSCLER THROMB VASC BIOL, 2011
KIM, CHO ET AL., CLIN RHEUMATOL, 2010
CARRASCO ET AL., CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2011
GAMBUZZA, LICATA ET AL., JOURNAL OF NEUROIMMUNOLOGY, 2011
FRESNO, ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 2011
VOLIN; KOCH, J INTERFERON CYTOKINE RES, 2011
AKASH, SHEN ET AL., JOURNAL OF PHARMACEUTICAL SCIENCES, 2012
GOH; MIDWOOD, RHEUMATOLOGY, 2012
DASU, RAMIREZ ET AL., CLINICAL SCIENCE, 2012
OUZIEL, GUSTOT ET AL., AM J PATHO, 2012
RAMIREZ; DASU, CURR DIABETES REV, 2012
OKIYAMA ET AL., ARTHRITIS RHEUM, 2012
CHEN ET AL., ARTHRITIS RESEARCH & THERAPY, 2013
HOLLE, WINDMOLLER ET AL., RHEUMATOLOGY (OXFORD, 2013
LI, WANG ET AL., PHARMACOLOGY & THERAPEUTICS, 2013
SEDIMBI, HAGGLOF ET AL., CELL MOL LIFE SCI, 2013
CASO, COSTA ET AL., MEDIATORS OF INFLAMMATION, 2014
CORDIGLIERI, MAROLDA ET AL., J AUTOIMMUN, 2014
JIALAL, MAJOR ET AL., J DIABETES COMPLICATIONS, 2014
KAPLAN, YAZGAN ET AL., SCAND J GASTROENTEROL, 2014
TALABOT-AYE ET AL., CYTOKINE, 2014
ZONG, DORPH ET AL., ANN RHEUM DI, 2014
BALLAK, STIENSTRA ET AL., CYTOKINE, 2015
TIMPER, SEELIG ET AL., J DIABETES COMPLICATIONS, 2015
SCHMIDT, MITTNACHT ET AL., J DERMATOL SCI, 1996
HOFFMANN, J INVESTIG DERMATOL SYMP PROC, 1999
GILLIET, CONRAD ET AL., ARCHIVES OF DERMATOLOGY, 2004
NIEBUHR, LANGNICKEL ET AL., ALLERGY, 2008
MILLER, ADV DERMATOL, 2008
TERHORST, KALALI ET AL., AM J CLIN DERMATOL, 2010
VIGUIER, GUIGUE ET AL.: "Annals of Internal Medicine", 2010
CEVIKBAS, STEINHOFF, J INVEST DERMATOL, 2012
MINKIS, AKSENTIJEVICH ET AL., ARCHIVES OF DERMATOLOGY, 2012
DISPENZA, WOLPERT ET AL., J INVEST DERMATOL, 2012
GRESNIGT; VAN DE VEERDONK, SEMINARS IN IMMUNOLOGY, 2013
SELWAY, KURCZAB ET AL., BMC DERMATOLOGY, 2013
WOLLINA, KOCH ET AL., INDIAN DERMATOL ONLINE, 2013
FOSTER, BALIWAG ET AL., THE JOURNAL OF IMMUNOLOGY, 2014
RAMIREZ CRUZ, MALDONADO BERNAL ET AL., REV ALERG MEX, 2004
JEYASEELAN, CHU ET AL., INFECTION AND IMMUNITY, 2005
SEKI, TASAKA ET AL., INFLAMMATION RESEARCH, 2010
XIANG, FAN ET AL., MEDIATORS OF INFLAMMATION, 2010
MARGARITOPOULOS, ANTONIOU ET AL., FIBROGENESIS & TISSUE REPAIR, 2010
HILBERATH, CARLO ET AL., THE FASEB JOURNAL, 2011
NADIGEL, PREFONTAINE ET AL., RESPIRATORY RESEARCH, 2011
KOVACH; STANDIFORD, INTERNATIONAL IMMUNOPHARMACOLOGY, 2011
BAUER, SHAPIRO ET AL., MOL MED, 2012
DENG, YANG ET AL., PLOS ONE, 2013
FREEMAN, MARTINEZ ET AL., RESPIRATORY RESEARCH, 2013
DUBANIEWICZ, A., HUMAN IMMUNOLOGY, 2013
LIU-BRYAN, SCOTT ET AL., ARTHRITIS & RHEUMATISM, 2005
PIGGOTT, EISENBARTH ET AL., J CLIN INVES, 2005
CHRISTENSEN, SHUPE ET AL., IMMUNITY, 2006
CARIO, INFLAMMATORY BOWEL DISEASES, 2010
NICKERSON, CHRISTENSEN ET AL., THE JOURNAL OF IMMUNOLOGY, 2010
RAKOFF-NAHOUM, HAO ET AL., IMMUNITY, 2006
HEIMESAAT, FISCHER ET AL., PLOS ONE, 2007
HEIMESAAT, NOGAI ET AL., GUT, 2010
KOBORI, YAGI ET AL., J GASTROENTEROL, 2010
SCHMIDT, RAGHAVAN ET AL., NAT IMMUNOL, 2010
SHI, MUCSI ET AL., IMMUNOLOGICAL REVIEWS, 2010
LEVENTHAL; SCHROPPEL, KIDNEY INT, 2012
CHEN, LIN ET AL., ARTHRITIS RES THER, 2013
HAO, LIU ET AL., CURR OPIN GASTROENTEROL, 2013
KREISEL; GOLDSTEIN, TRANSPLANT INTERNATIONAL, 2013
WALSH, CARTHY ET AL., CYTOKINE & GROWTH FACTOR REVIEWS, 2013
ZHU, JIANG ET AL., AUTOIMMUNITY, 2013
YAP; LAI, NEPHROLOGY, 2013
VENNEGAARD, DYRING-ANDERSEN ET AL., CONTACT DERMATITIS, 2014
D'ELIA, BRUCATO ET AL., CLIN EXP RHEUMATOL, 2015
JAIN, THONGPRAYOON ET AL., AM J CARDIOL., 2015
LI, ZHANG ET AL., ONCOL REP., 2015
AKOUM, LAWSON ET AL., HUMAN REPRODUCTION, 2007
ALLHORN, BOING ET AL., REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2008
LAWSON, BOURCIER ET AL., JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2008
SIKORA, MIELCZAREK-PALACZ ET AL., AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2012
KHAN, KITAJIMA ET AL., JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2013
SANTULLI, BORGHESE ET AL., HUMAN REPRODUCTION, 2013
SIVAGURUNATHAN ET AL., CLINICA CHIMICA ACTA, 2012
FALCK-HANSEN, KASSITERIDI ET AL., INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013
KAARNIRANTA; SALMINEN, J MOL MED (BERL, 2009
SUN; PEARLMAN, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2009
REDFERN; MCDERMOTT, EXPERIMENTAL EYE RESEARCH, 2010
KEZIC, TAYLOR ET AL., J LEUKOC BIOL, 2011
CHANG, MCCLUSKEY ET AL., CLINICAL & EXPERIMENTAL OPHTHALMOLOGY, 2012
GUO, GAO ET AL., IMMUNOL CELL BIOL, 2012
LEE, HATTORI ET AL., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012
QI, ZHAO ET AL., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014
ZHAO, ZHAO ET AL., SCAND J GASTROENTEROL, 2011
BENIAS, GOPAL ET AL., CLIN RES HEPATOL GASTROENTEROL, 2012
YANG, L.; E. SEKI, FRONT PHYSIOL, 2012
LIU, HU ET AL., BIOCHIM BIOPHYS ACTA, 2015
NOZAKI, SAIBARA ET AL., ALCOHOL CLIN EXP RES, 2004
CSAK, T.; A. VELAYUDHAM ET AL., AM J PHYSIOL GASTROINTEST LIVER PHYSIOL, 2011
MIURA, KODAMA ET AL., GASTROENTEROLOGY, 2010
KAMARI, SHAISH ET AL., J HEPATOL, 2011
YE, LI ET AL., GUT, 2012
ROH, SEKI, J GASTROENTEROL HEPATOL, 2013
CECCARELLI, S.; V. NOBILI ET AL., WORLD J GASTROENTEROL, 2014
MIURA; OHNISHI, WORLD J GASTROENTEROL, 2014
STOJSAVLJEVIC, PALCIC ET AL., WORLD J GASTROENTEROL, 2014
SUZUKI, SUZUKI ET AL., JOURNAL OFTHE AMERICAN SOCIETY OF NEPHROLOGY, 2008
HAHN, CHO ET AL., PEDIATRIC NEPHROLOGY, 2009
CONTI, SPINELLI ET AL., CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2010
BAO, NA ET AL., JOURNAL OF CLINICAL IMMUNOLOGY, 2011
ROSA RAMIREZ; RAVI KRISHNA DASU, CURR DIABETES REV, 2012
URBONAVICIUTE, STARKE ET AL., ARTHRITIS & RHEUMATISM, 2013
BATAL ET AL., TRANSPLANTATION, 2014
LIN; TANG, NEPHROLOGY DIALYSIS TRANSPLANTATION, 2014
ZAWADA, ROGACEV ET AL., EPIGENETIC, 2014
ELSHERBINY; AL-GAYYAR, CYTOKINE, 2016
YANG ET AL., MOL MED REP, 2016
OYAMA, BLAIS ET AL., CIRCULATION, 2004
TIMMERS, SLUIJTER ET AL., CIRCULATION RESEARCH, 2008
FANG; HU, MED SCI MONIT, 2011
BIJANI, INTERNATIONAL REVIEWS OF IMMUNOLOGY, 2012
BOMFIM, DOS SANTOS ET AL., CLIN SCI (LOND, 2012
CHRISTIA; FRANGOGIANNIS, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2013
THOMPSON; WEBB, CLIN SCI (LOND, 2013
HERNANZ, MARTINEZ-REVELLES ET AL., BRITISH JOURNAL OF PHARMACOLOGY, 2015
FRANGOGIANNIS, CURR OPIN CARDIOL, 2015
BOMFIM, ECHEM ET AL., LIFE SCIENCES, 2015
BROUGH, TYRRELL ET AL., TRENDS IN PHARMACOLOGICAL SCIENCES, 2011
CARTY; BOWIE, BIOCHEMICAL PHARMACOLOGY, 2011
DENES, KITAZAWA, CHENG ET AL., THE JOURNAL OF IMMUNOLOGY, 2011
LIM, KOU ET AL., THE AMERICAN JOURNAL OF PATHOLOGY, 2011
; BERAUD; MAGUIRE-ZEISS, PARKINSONISM & RELATED DISORDERS, 2012
DENES, WILKINSON ET AL., DISEASE MODELS & MECHANISMS, 2013
NOELKER, MOREL ET AL., SCI. REP, 2013
WANG, WANG ET AL., STROKE, 2013
XIANG, CHAO ET AL., REV NEUROSCI, 2015
LEE, LEE ET AL., J NEUROINFLAMMATION, 2015
WOLF, LIVSHITS ET AL., BRAIN, BEHAVIOR, AND IMMUNITY, 2008
KIM, LEE ET AL., TOLL-LIKE RECEPTORS: ROLES IN INFECTION AND NEUROPATHOLOGY, 2009
DEL REY, APKARIAN ET AL.: "Annals of the New York Academy of Sciences", 2012
GUERRERO, CUNHA ET AL., EUROPEAN JOURNAL OF PHARMACOLOGY, 2012
KWOK, HUTCHINSON ET AL., PLOS ONE, 2012
NICOTRA, LORAM ET AL., EXPERIMENTAL NEUROLOGY, 2012
CHOPRA; COOPER, J NEUROIMMUNE PHARMACOL, 2013
DAVID, RATNAYAKE ET AL., NEUROBIOLOGY OF DISEASE, 2013
HAN, ZHAO ET AL., NEUROSCIENCE, 2013
LIU; JI, PFLUGERS ARCH., 2013
STOKES, CHEUNG ET AL., JOURNAL OF NEUROINFLAMMATION, 2013
ZHAO, ZHANG ET AL., NEUROSCIENCE, 2013
LIU, ZHANG ET AL., CELL RESEARCH, 2014
PARK, STOKES ET AL., CANCER CHEMOTHER PHARMACOL, 2014
VAN DER WATT, WILKINSON ET AL., BMC INFECT DIS, 2014
WON, K. A., M. J. KIM ET AL., J PAIN, 2014
MIN, AHMAD ET AL., PHOTOCHEM PHOTOBIOL, 2015
SCHREPF, BRADLEY ET AL., BRAIN BEHAV IMMUN, 2015
WONG, L.; J. D. DONE ET AL., PROSTATE, 2015
NGO, YOUNG ET AL., NATURE, 2011
PUENTE, PINYOL ET AL., NATURE, 2011
OCHI, NGUYEN ET AL., J EXP MED, 2012
SRIVASTAVA, GENG ET AL., CANCER RESEARCH, 2012
TREON, XU ET AL., NEW ENGLAND JOURNAL OF MEDICINE, 2012
CHOI, KIM ET AL., HUMAN PATHOLOGY, 2013
LIANG, CHEN ET AL., CLINICAL CANCER RESEARCH, 2013
KFOURY, A., K. L. CORF ET AL., JOURNAL OFTHE NATIONAL CANCER INSTITUTE, 2013
SZCZEPANSKI, CZYSTOWSKA ET AL., CANCER RES, 2009
ZHANG, HE ET AL., MOL BIOL REP, 2009
WANG, QIAN ET AL., BR J CANCER KIM, 2010
JO ET AL., WORLD J SURG ONCOL, 2012
ZHAO, ZHANG ET AL., FRONT IMMUNOL, 2014
CHEN, ZHAO ET AL., INT J CLIN EXP PATHOL, 2015
NARAYANAN, CORRALES ET AL., CORNEA, 2008
BRENNER, RUZICKA ET AL., BRITISH JOURNAL OF DERMATOLOGY, 2009
HENDERSON; GOLDBACH-MANSKY, CLINICAL IMMUNOLOGY, 2010
DINARELLO, EUROPEAN JOURNAL OF IMMUNOLOGY, 2011
GUL, TUGAL-TUTKU ET AL., ANN RHEUM DIS, 2012
PETTERSSON: "Annals of MedicinePetterson", 2012
RUPERTO, BRUNNER ET AL., NEW ENGLAND JOURNAL OF MEDICINE, 2012
NORDSTRÖM, KNIGHT ET AL., THE JOURNAL OF RHEUMATOLOGY, 2012
VIJMASI, CHEN ET AL., MOL VIS, 2013
YAMADA, ARAKAKI ET AL., OPINION ON THERAPEUTIC TARGETS, 2013
DE KONING, CLIN TRANSL ALLERGY, 2014
AKCAY, NGUYEN ET AL., JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011
KANG, HOMER ET AL., THE JOURNAL OF IMMUNOLOGY, 2007
IMAOKA, HOSHINO ET AL., EUROPEAN RESPIRATORY JOURNAL, 2008
COUILLIN, VASSEUR ET AL., THE JOURNAL OF IMMUNOLOGY, 2009
ABBATE, KONTOS ET AL., THE AMERICAN JOURNAL OF CARDIOLOGY, 2010
LLOYD, CURRENT OPINION IN IMMUNOLOGY, 2010
PAUWELS, BRACKE ET AL., EUROPEAN RESPIRATORY JOURNAL, 2011
HAENUKI, MATSUSHITA ET AL., JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012
YIN, LI ET AL., CLINICAL & EXPERIMENTAL IMMUNOLOGY, 2012
ABBATE, VAN TASSELL ET AL., THE AMERICAN JOURNAL OF CARDIOLOGY, 2013
ALEXANDER-BRETT ET AL., THE JOURNAL OF CLINICAL INVESTIGATION, 2013
BUNTING, SHADIE ET AL., BIOMED RESEARCH INTERNATIONAL, 2013
BYERS, ALEXANDER-BRETT ET AL., THE JOURNAL OF CLINICAL INVESTIGATION, 2013
KAWAYAMA, OKAMOTO ET AL., J INTERFERON CYTOKINE RES, 2013
MARTINEZ-GONZÄLEZ, ROCA ET AL., AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2013
NAKANISHI, YAMAGUCHI ET AL., PLOS ONE, 2013
QIU, LI ET AL., IMMUNOLOGY, 2013
LI, GUABIRABA ET AL., JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014
SALUJA, KETELAAR ET AL., MOLECULAR IMMUNOLOGY, 2014
LUGRIN, PARAPANOV ET AL., THE JOURNAL OF IMMUNOLOGY, 2015
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, vol. 49, 2014, pages 117 - 133
BIOORG. MED. CHEM. LETT., vol. 16, 2006, pages 2842 - 2845
BEISPIEL EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 8, 2003, pages 1559 - 1568
CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 38, no. 9, 1990, pages 2446 - 2458
SYNTHETIC COMMUNICATIONS, vol. 42, 2012, pages 658 - 666
TETRAHEDRON, vol. 60, no. 51, 2004, pages 11869 - 11874
DALTON TRANSACTIONS, vol. 43, no. 19, 2014, pages 7176 - 7190
CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND, vol. 15, 2003, pages 1948 - 1949
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2, no. 327-33, 2002
SYNTHESIS, vol. 10, 2004, pages 1619 - 1624
JOURNAL OFTHE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 32, 2013, pages 12122 - 12134
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 24, no. 16, 2014, pages 4039 - 4043
ANDREW B. HUGHES: "Building Blocks, Catalysis and Coupling Chemistry", vol. 3, WILEY, article "Amino Acids, Peptides and Proteins in Organic Chemistry"
"Peptide-Coupling Reagents", article "Kapitel 12", pages: 407 - 442
CHEM. SOC. REV., 2009, vol. 38, pages 606
BIOORG. MED. CHEM. LETT., vol. 18, 2008, pages 2093
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis, Fourth Edition,", ISBN: 9780471697541
HIROSE, KURODA ET AL., PAIN PRACTICE, 2016
INDO, CLINICAL GENETICS, 2012
TESSAROLLO, L., CYTOKINE & GROWTH FACTOR REVIEWS, 1998
GARCIA-SUÄREZ, GERMANÄ ET AL., JOURNAL OF NEUROIMMUNOLOGY, 2000
COPPOLA, BARRICK ET AL., DEVELOPMENT, 2004
DISSEN, GARCIA-RUDAZ ET AL., SEMINARS IN REPRODUCTIVE MEDICINE, 2009
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BIP PATENTS (DE)
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