NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME

Title:

NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO/1999/061414

Kind Code:

A1

Abstract:

Compounds represented by general formula (1) which are useful as remedies and preventives for diseases caused by acceleration in the sodium/proton exchange system, wherein R¿1?, R¿2?, R¿3?, R¿4? and R¿5? represent each hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, a saturated aromatic ring, acyl, etc.; Y¿1?, Y¿2?, Y¿3? and Y¿4? represent each a single bond, -CH¿2?-, -O-, -CO-, etc., provided that at least two of Y¿1? to Y¿4? represent each a group other than a single bond; and Z may be absent or one or more Zs may be present and each represents alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, a saturated aromatic ring, halogeno, carboxy, alkoxycarbonyl, an aromatic group, acyl, etc.

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Inventors:

KITANO MASAHUMI (JP)
OHASHI NAOHITO (JP)

Application Number:

PCT/JP1999/002738

Publication Date:

December 02, 1999

Filing Date:

May 25, 1999

Export Citation:

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Assignee:

SUMITOMO PHARMA (JP)
KITANO MASAHUMI (JP)
OHASHI NAOHITO (JP)

International Classes:

C07C279/22; C07C317/44; C07C323/62; C07D215/54; C07D223/16; C07D225/06; (IPC1-7): C07C279/22; A61K31/165; A61K31/255; A61K31/395; A61K31/47; A61K31/55; C07C277/00; C07D215/54; C07D223/16; C07D225/06; C07D227/00

Domestic Patent References:

WO1998055475A1

1998-12-10

Foreign References:

JPH08291131A

1996-11-05

Other References:

BEDAIR A H, ALY F M, EL-ASSY R K M: "BIOLOGICALLY ACTIVE SULFONAMIDES DERIVED FROM ALPHA-PYRONES", INDIAN JOURNAL OF CHEMISTRY, JODHPUR, IN, vol. 26B, no. 01, 1 January 1987 (1987-01-01), IN, pages 91 - 94, XP002919458
See also references of EP 1083166A4

Attorney, Agent or Firm:

Asamura, Kiyoshi (Room 331 2-1 Ohtemachi 2-chome Chiyoda-ku, Tokyo, JP)

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