NOVEL SULFONAMIDE DERIVATIVE AND SALT THEREOF

WIPO Patent Application WO/2008/136378

A1

Disclosed is a compound represented by the following general formula: (wherein R1 represents a hydrogen atom or the like; R2 represents an optionally substituted alkyl or aryl group or the like; R3 and R4 may be the same or different and each represents an aryl group or the like; R5 represents a hydrogen atom or the like; X1 represents an alkylene group, a bonding hand or the like; X2 represents a bonding hand or the like; Y1 represents a bonding hand or the like; and Z1 and Z2 each represents CH or the like) or a salt thereof. Since the compound or a salt thereof has a strong PGE2 production inhibitory activity, it is useful for treatment or prevention of diseases and conditions associated with PGE2.

YOKOTANI JUNICHI (JP)
TANIGUCHI YOICHI (JP)
KONISHI YOSHITAKE (JP)
TADA YUKIE (JP)
YANAI MINORI (JP)
KATAI MASAKI (JP)

PCT/JP2008/058015

November 13, 2008

April 25, 2008

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TOYAMA CHEMICAL CO LTD (JP)
YOKOTANI JUNICHI (JP)
TANIGUCHI YOICHI (JP)
KONISHI YOSHITAKE (JP)
TADA YUKIE (JP)
YANAI MINORI (JP)
KATAI MASAKI (JP)

C07C311/08; A61K31/341; A61K31/343; A61K31/381; A61K31/40; A61K31/404; A61K31/415; A61K31/4164; A61K31/426; A61K31/437; A61K31/4406; A61K31/47; A61K31/472; A61K31/495; A61K31/4965; A61K31/505; A61P29/00; A61P43/00; C07C311/13; C07C311/21; C07D207/335; C07D207/34; C07D209/08; C07D213/53; C07D215/12; C07D217/04; C07D231/14; C07D233/26; C07D239/26; C07D241/28; C07D277/20; C07D277/28; C07D277/56; C07D295/12; C07D295/14; C07D307/81; C07D317/58; C07D319/18; C07D333/20; C07D471/04

JPH11510485A

1999-09-14

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, vol. 18, no. 2, 2007, pages 384 - 390

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