Title:
NOVEL SULFONAMIDE DERIVATIVE WITH FUSED PYRIMIDINE SKELETON, HAVING EPIDERMAL GROWTH FACTOR RECEPTOR MUTATION INHIBITORY EFFECT
Document Type and Number:
WIPO Patent Application WO/2020/060268
Kind Code:
A1
Abstract:
The present invention relates to: a novel sulfonamide derivative with a fused pyrimidine skeleton, represented by chemical formula I; a solvate thereof or pharmaceutically acceptable salts thereof; and a pharmaceutical composition containing same as an active ingredient. A novel sulfonamide derivative with a fused pyrimidine skeleton, of the present invention, can effectively inhibit cancer cell growth and drug resistance, which are caused by a mutation in a tyrosine kinase domain of an epidermal growth factor receptor, or the growth of cancer cells having the resistance.
Inventors:
JANG SUN YOUNG (KR)
KIM MI RA (KR)
JEON JI YOUNG (KR)
KWAK EUN JOO (KR)
LEE SUN HOE (KR)
KIM MI RA (KR)
JEON JI YOUNG (KR)
KWAK EUN JOO (KR)
LEE SUN HOE (KR)
Application Number:
PCT/KR2019/012207
Publication Date:
March 26, 2020
Filing Date:
September 20, 2019
Export Citation:
Assignee:
HANMI PHARM IND CO LTD (KR)
International Classes:
C07D487/04; A61K31/519; A61P35/00; C07D498/04; C07D513/04
Domestic Patent References:
| WO2018098561A1 | 2018-06-07 | |||
| WO2017066428A1 | 2017-04-20 | |||
| WO2014140065A1 | 2014-09-18 |
Foreign References:
| KR20160007677A | 2016-01-20 | |||
| KR20170141783A | 2017-12-26 | |||
| KR20190067699A | 2019-06-17 | |||
| US20160083369A1 | 2016-03-24 |
Other References:
CHOE, H. ET AL.: "Structure-Activity Relationship Study of 2,4-Dianilinopyrimidine Containing Methanesulfonamide (TRE-069) as Potent and Selective Epidermal Growth Factor Receptor T790M/C797S Mutant Inhibitor for Anticancer Treatment", BULLETIN- KOREAN CHEMICAL SOCIETY, vol. 38, 2017, pages 1353 - 1357, XP055561541, DOI: 10.1002/bkcs.11287
WELLS A, INT J BIOCHEM CELL BIOL, vol. 31, 1999, pages 637
NANCY E. HYNESHEIDI A. LANE, NATURE REVIEWS CANCER, vol. 5, 2005, pages 341
HELENA A. YU ET AL., CLIN CANCER RES., vol. 19, no. 8, 2013, pages 2240
DANAN LI ET AL., CANCER CELL, vol. 12, 2007, pages 81
ANJA MICHALCZYK ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 2008, pages 3482
MARTIN L. SOS ET AL., CANCER RES., vol. 70, 2010, pages 868
THRESS, K. S. ET AL., NAT. MED., vol. 21, 2015, pages 560
SHUHANG WANG ET AL., JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 9, 2016, pages 59
TAN ET AL., MOLECULAR CANCER, vol. 17, 2018, pages 29
See also references of EP 3842435A4
WELLS A, INT J BIOCHEM CELL BIOL, vol. 31, 1999, pages 637
NANCY E. HYNESHEIDI A. LANE, NATURE REVIEWS CANCER, vol. 5, 2005, pages 341
HELENA A. YU ET AL., CLIN CANCER RES., vol. 19, no. 8, 2013, pages 2240
DANAN LI ET AL., CANCER CELL, vol. 12, 2007, pages 81
ANJA MICHALCZYK ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 2008, pages 3482
MARTIN L. SOS ET AL., CANCER RES., vol. 70, 2010, pages 868
THRESS, K. S. ET AL., NAT. MED., vol. 21, 2015, pages 560
SHUHANG WANG ET AL., JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 9, 2016, pages 59
TAN ET AL., MOLECULAR CANCER, vol. 17, 2018, pages 29
See also references of EP 3842435A4
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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