Title:
NOVEL T-CELL PROTEINS, PEPTIDES AND ANTIBODIES DERIVED THEREFROM AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2004011496
Kind Code:
A3
Abstract:
Described are polynucleotides encoding novel T-cell proteins and biologically fragments thereof, which are specifically up-regulated during early events in T-cell activation. Furthermore, vectors are described comprising said polynucleotides and/or host cells transformed therewith. Additionally, antisense constructs to said polynucleotides are described. Furthermore, methods and uses for modulating immune responses through the T-cell protein as well as pharmaceutical compositions comprising agents which act on the T-cell protein are described. Also, uses of said polynucleotides, vectors, proteins or antibodies for the preparation of diagnostic and pharmaceutical compositions for use, inter alia, in organ transplantation, for the treatment of autoimmune, allergic or infectious diseases, or for treatment of tumors are provided.
Inventors:
UTKU NALAN (DE)
Application Number:
PCT/EP2002/007440
Publication Date:
October 27, 2005
Filing Date:
July 04, 2002
Export Citation:
Assignee:
UTKU NALAN (DE)
International Classes:
C07K14/47; (IPC1-7): C07K14/47; A61K38/17; C07K16/18; C12N5/10; C12N15/11
Other References:
UTKU N ET AL: "THE HUMAN HOMOLOG OF DROSOPHILA CORNICHON PROTEIN IS DIFFERENTIALLYEXPRESSED IN ALLOACTIVATED T-CELLS", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1449, no. 3, 1999, pages 203 - 210, XP000982809, ISSN: 0006-3002
UTKU N ET AL: "PREVENTION OF ACUTE ALLOGRAFT REJECTION BY ANTIBODY TARGETING OF TIRC7, A NOVEL T CELL MEMBRANE PROTEIN", IMMUNITY, CELL PRESS, US, vol. 9, October 1998 (1998-10-01), pages 509 - 518, XP002188110
HEINEMAN T ET AL: "GENOMIC ORGANIZATION OF THE GENE CODING FOR TIRC7, A NOVEL MEMBRANEPROTEIN ESSENTIAL FOR T CELL ACTIVATION", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 57, no. 3, 1 May 1999 (1999-05-01), pages 398 - 406, XP000999606
See also references of EP 1581554A2
UTKU N ET AL: "PREVENTION OF ACUTE ALLOGRAFT REJECTION BY ANTIBODY TARGETING OF TIRC7, A NOVEL T CELL MEMBRANE PROTEIN", IMMUNITY, CELL PRESS, US, vol. 9, October 1998 (1998-10-01), pages 509 - 518, XP002188110
HEINEMAN T ET AL: "GENOMIC ORGANIZATION OF THE GENE CODING FOR TIRC7, A NOVEL MEMBRANEPROTEIN ESSENTIAL FOR T CELL ACTIVATION", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 57, no. 3, 1 May 1999 (1999-05-01), pages 398 - 406, XP000999606
See also references of EP 1581554A2
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