Title:
NOVEL TACHYKININ PEPTIDES, PRECURSOR PEPTIDES THEREOF AND GENES ENCODING THE SAME
Document Type and Number:
WIPO Patent Application WO/2001/009171
Kind Code:
A1
Abstract:
Tachykinin peptides isolated and purified from the posterior salivary gland of common octopus which is a mollusc. These tachykinin peptides, which provide a new approach for developing drugs and pesticides through studies on the structural activity correlation at the molecular level, are characterized by: (1) having 12 amino acid residues; (2) having Lys at the N-terminus; and (3) having the following amino acid sequence (I) consisting of 5 amino acids from the C-terminus: -Phe-Xaa-Gly-Leu-Met-NH¿2? wherein Xaa represents Val, Ile, Phe or Tyr. Among all, novel peptides having the following amino acid sequences (1) H-Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Val-Gly-Leu-Met-NH¿2?; and (2) H-Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Ile-Gly-Leu-Met-NH¿2?.
Inventors:
MINAKATA HIROYUKI (JP)
IWAKOSHI EIKO (JP)
KURODA KYOKO (JP)
IWAKOSHI EIKO (JP)
KURODA KYOKO (JP)
Application Number:
PCT/JP2000/004944
Publication Date:
February 08, 2001
Filing Date:
July 25, 2000
Export Citation:
Assignee:
SUNTORY LTD (JP)
MINAKATA HIROYUKI (JP)
IWAKOSHI EIKO (JP)
KURODA KYOKO (JP)
MINAKATA HIROYUKI (JP)
IWAKOSHI EIKO (JP)
KURODA KYOKO (JP)
International Classes:
A61K38/00; A61P1/00; A61P9/08; A61P9/12; C07K1/18; C07K1/20; C12N15/09; C07K7/08; C07K7/22; C07K14/575; C12N1/00; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12R1/19; (IPC1-7): C07K7/08; C12N15/12; C12N1/21; C12P21/02; A61K38/10; A61P9/08
Other References:
IWAKOSHI E. ET AL.: "Isolation of two novel tachykinins from the posterior salivary gland of Octopus Vulgaris", ZOOLOGICAL SCIENCE,, vol. 16, December 1999 (1999-12-01), (TOKYO), pages 103, XP002930763
IWAKOSHI E. ET AL.: "Cardioactive peptides isolated from the brain of Japanese Ootopus, Octopus minor", PEPTIDES,, vol. 21, no. 5, May 2000 (2000-05-01), pages 623 - 630, XP002930764
MARTIN R. ET AL.: "The neurosecretory system of the octopus vena cava:(A) neurohemal organ", EXPERIENTIA,, vol. 43, no. 5, 1987, pages 537 - 543, XP002930765
CHAMPAGNE D.E. ET AL.: "Sialokinin I and II: Vasodilatory tachykinins from the yellow fever mosquito aedes aegypti", PROC. NATL. ACAD. SCI. USA,, vol. 91, no. 1, 1994, pages 138 - 142, XP002930766
IWAKOSHI E. ET AL.: "Cardioactive peptides isolated from the brain of Japanese Ootopus, Octopus minor", PEPTIDES,, vol. 21, no. 5, May 2000 (2000-05-01), pages 623 - 630, XP002930764
MARTIN R. ET AL.: "The neurosecretory system of the octopus vena cava:(A) neurohemal organ", EXPERIENTIA,, vol. 43, no. 5, 1987, pages 537 - 543, XP002930765
CHAMPAGNE D.E. ET AL.: "Sialokinin I and II: Vasodilatory tachykinins from the yellow fever mosquito aedes aegypti", PROC. NATL. ACAD. SCI. USA,, vol. 91, no. 1, 1994, pages 138 - 142, XP002930766
Attorney, Agent or Firm:
Kusama, Osamu (5-12 Iidabashi 4-chome Chiyoda-ku, Tokyo, JP)
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