Title:
NOVEL TECHNIQUE FOR TREATING CANCER USING STRUCTURALLY-REINFORCED S-TUD
Document Type and Number:
WIPO Patent Application WO/2018/169063
Kind Code:
A1
Abstract:
Provided is a novel technique for treating cancer using structurally-reinforced S-TuD. Provided are: a composition for the prevention or treatment of tumors, said composition comprising an miRNA inhibitory complex including RNA of analog thereof; and a method for preventing or treating tumors using said composition. The miRNA inhibitory complex preferably includes at least one double-stranded structure and an miRNA-binding sequence. Two strands of the miRNA binding sequence preferably bind individually to two strands on at least one end of the double-stranded structure. According to some of the aspects of the present invention, there is provided a transmit system for transmitting such an miRNA inhibitory complex.
Inventors:
IBA HIDEO (JP)
HARAGUCHI TAKESHI (JP)
NANKAI HIROKAZU (JP)
SATO HIDEAKI (JP)
HARAGUCHI TAKESHI (JP)
NANKAI HIROKAZU (JP)
SATO HIDEAKI (JP)
Application Number:
PCT/JP2018/010514
Publication Date:
September 20, 2018
Filing Date:
March 16, 2018
Export Citation:
Assignee:
UNIV CHIBA NAT UNIV CORP (JP)
GENEDESIGN INC (JP)
NOF CORP (JP)
GENEDESIGN INC (JP)
NOF CORP (JP)
International Classes:
A61K31/7105; A61K9/14; A61K31/713; A61P1/00; A61P11/00; A61P15/00; A61P35/00; A61P43/00; C12N15/00
Domestic Patent References:
| WO2010047216A1 | 2010-04-29 | |||
| WO2005021570A1 | 2005-03-10 | |||
| WO2016121942A1 | 2016-08-04 | |||
| WO2013073480A1 | 2013-05-23 | |||
| WO2016126844A1 | 2016-08-11 | |||
| WO2017047097A1 | 2017-03-23 | |||
| WO2010047216A1 | 2010-04-29 |
Foreign References:
| JP2016004252W | 2016-09-16 | |||
| JPS4936343B1 | 1974-09-30 | |||
| JP4731324B2 | 2011-07-20 | |||
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| JP2016078345W | 2016-09-27 | |||
| JP2013544251A | 2013-12-12 | |||
| JP2017053124A | 2017-03-16 |
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CARCINOGENESIS, vol. 38, no. 4, 1 April 2017 (2017-04-01), pages 425 - 431
CELL DEATH AND DIFFERENTIATION, vol. 21, 2014, pages 774 - 782
EXP THER MED., vol. 14, no. 1, July 2017 (2017-07-01), pages 657 - 663
CANCER CELL., vol. 25, no. 4, 14 April 2014 (2014-04-14), pages 469 - 483
NAT COMMUN., vol. 4, 2013, pages 1877
INT J CLIN EXP PATHOL., vol. 8, no. 4, 1 April 2015 (2015-04-01), pages 3827 - 34
MED MOL MORPHOL., vol. 50, no. 2, June 2017 (2017-06-01), pages 76 - 85
ONCOTARGET, vol. 6, no. 30, 6 October 2015 (2015-10-06), pages 30239 - 50
CLIN TRANSL ONCOL, vol. 17, 2015, pages 209 - 214
ONCOTARGET, vol. 8, 2017, pages 74276 - 74286
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WU XYAMAMOTO HNAKANISHI HYAMAMOTO YINOUE ATEI M ET AL.: "Innovative Delivery of siRNA to Solid Tumors by Super Carbonate Apatite", PLOS ONE, vol. 10, no. 3, 2015, pages e0116022, XP055531405, doi:10.1371/journal.pone.0116022
See also references of EP 3597197A4
JACKSON AL ET AL., RNA, vol. 12, no. 7, 2006, pages 1179 - 1187
LEWIS BP ET AL., CELL, vol. 120, 2005, pages 15 - 20
BRENNECKE ET AL., PLOS BIOLOGY, vol. 3, 2005, pages 0404 - 0418
LEWIS ET AL., CELL, vol. 115, 2003, pages 787 - 798
KIRIAKIDOU ET AL., GENES & DEVELOPMENT, vol. 18, 2004, pages 1165 - 1178
ALTSCHUL, S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
ALTSCHUL S.F. ET AL., NATURE GENET., vol. 3, 1993, pages 266 - 272
MADDEN, T.L. ET AL., METH. ENZYMOL., vol. 266, 1996, pages 131 - 141
ALTSCHUL S.F. ET AL., NUCLEIC ACIDS RES, vol. 25, 1997, pages 3389 - 3402
ZHANG J.MADDEN T.L., GENOME RES., vol. 7, 1997, pages 649 - 656
TATIANA A ET AL., FEMS MICROBIOL. LETT., vol. 174, 1999, pages 247 - 250
KRUTZFELDT, J. ET AL., NUCLEIC ACIDS RES., vol. 34, 2006, pages 2294 - 2304
BOUTLA, A. ET AL., NUCLEIC ACIDS RES., vol. 31, 2003, pages 4973 - 4980
HUTVAGNER, G. ET AL., PLOS BIOL., vol. 2, 2004, pages E98
CHAN, J.A. ET AL., CANCER RES., vol. 65, 2005, pages 6029 - 6033
ESAU, C. ET AL., J. BIOL. CHEM., vol. 279, 2004, pages 52361 - 52365
ESAU, C. ET AL., CELL METAB., vol. 3, 2006, pages 87 - 98
PRADEEP S. PALLAN ET AL., CHEM COMMUN (CAMB)., vol. 48, no. 66, 25 August 2012 (2012-08-25), pages 8195 - 8197
J.ORG.CHEM., vol. 75, 2010, pages 1569 - 1581
NATURE CELL BIOLOGY, vol. 10, 2008, pages 593 - 601
BIOMED PHARMACOTHER, vol. 91, July 2017 (2017-07-01), pages 823 - 830
BIOMED REP., vol. 5, no. 4, October 2016 (2016-10-01), pages 395 - 402
FRONT MED (LAUSANNE, vol. 2, 2015, pages 64
BAYRAKTAR, R.VAN ROOSBROECK, K., CANCER METASTASIS REV, vol. 37, 2018, pages 33
PROC NATL ACAD SCI U S A, vol. 103, 2006, pages 2257 - 61
ONCOTARGET, vol. 7, no. 51, 20 December 2016 (2016-12-20), pages 84508 - 84519
STEM CELLS., vol. 32, no. 4, April 2014 (2014-04-01), pages 959 - 73
CARCINOGENESIS, vol. 38, no. 4, 1 April 2017 (2017-04-01), pages 425 - 431
CELL DEATH AND DIFFERENTIATION, vol. 21, 2014, pages 774 - 782
EXP THER MED., vol. 14, no. 1, July 2017 (2017-07-01), pages 657 - 663
CANCER CELL., vol. 25, no. 4, 14 April 2014 (2014-04-14), pages 469 - 483
NAT COMMUN., vol. 4, 2013, pages 1877
INT J CLIN EXP PATHOL., vol. 8, no. 4, 1 April 2015 (2015-04-01), pages 3827 - 34
MED MOL MORPHOL., vol. 50, no. 2, June 2017 (2017-06-01), pages 76 - 85
ONCOTARGET, vol. 6, no. 30, 6 October 2015 (2015-10-06), pages 30239 - 50
CLIN TRANSL ONCOL, vol. 17, 2015, pages 209 - 214
ONCOTARGET, vol. 8, 2017, pages 74276 - 74286
ONCOL REP., vol. 33, no. 5, May 2015 (2015-05-01), pages 2592 - 8
ONCOGENE, vol. 34, no. 36, 3 September 2015 (2015-09-03), pages 4767 - 76
M. MIZUK. KOUMOTOT. KIMURAK. SAKURAIS. SHINKAI, BIOMATERIALS, vol. 25, 2004, pages 3109
DRUG DELIVERY SYSTEM, vol. 25-6, 2010, pages 607 - 614
WU XYAMAMOTO HNAKANISHI HYAMAMOTO YINOUE ATEI M ET AL.: "Innovative Delivery of siRNA to Solid Tumors by Super Carbonate Apatite", PLOS ONE, vol. 10, no. 3, 2015, pages e0116022, XP055531405, doi:10.1371/journal.pone.0116022
See also references of EP 3597197A4
Attorney, Agent or Firm:
YAMAMOTO Shusaku et al. (JP)
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