NOVEL TETRAHYDROBENZINDOLONE DERIVATIVES

Title:

NOVEL TETRAHYDROBENZINDOLONE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1998/027059

Kind Code:

A1

Abstract:

Compounds represented by general formula (I) or pharmaceutically acceptable salts thereof and a process for producing the same. Because of having an inhibitory activity on the bonding of progesterone to its receptor, these compounds are usable as remedies and preventives for diseases in which progesterone participates. In particular, these compounds are useful as anticancer agents for mammary cancer and ovarian cancer, remedies for uterus myoma, endometriosis, meningioma and myeloma, abortifacients, oral contraceptives, and remedies and preventives for osteoporosis and menopausual symptoms. In said formula, R?1� represents alkyl or aralkyl; R?2� represents hydrogen, alkylcarbonyl, cycloalkyl- carbonyl, aromatic acyl, saturated heterocyclic acyl, alkyl, alkenyl, aralkyl, carbamoyl, alkylcarbamoyl, aromatic carbamoyl, aralkylcarbamoyl, alkylamino-carbonyl, cycloalkylcarbamoyl, alkoxycarbonyl, aryloxycarbonyl, heteroaromatic thiocarbonyl, saturated heterocyclic thiocarbonyl or alkylthiocarbamoyl; and R?3� represents hydrogen, hydroxy, alkyloxy, alkylcarbonyloxy, alkylthio or arylthio.

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Inventors:

KURIHARA KENICHI (JP)
SHINEI RIE (JP)
KURATA YASUSHI (JP)
TABATA YUJI (JP)
TANABE KIYOSHI (JP)
OKONOGI TSUNEO (JP)

Application Number:

PCT/JP1997/004683

Publication Date:

June 25, 1998

Filing Date:

December 18, 1997

Export Citation:

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Assignee:

MEIJI SEIKA KAISHA (JP)
KURIHARA KENICHI (JP)
SHINEI RIE (JP)
KURATA YASUSHI (JP)
TABATA YUJI (JP)
TANABE KIYOSHI (JP)
OKONOGI TSUNEO (JP)

International Classes:

C07D209/60; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D521/00; (IPC1-7): C07D209/60; A61K31/40; A61K31/415; A61K31/44; A61K31/445; A61K31/495; A61K31/535; C07D401/12; C07D403/12; C07D405/12; C07D409/12

Foreign References:

JPH08277253A	1996-10-22
JPH07215935A	1995-08-15

Other References: