Title:
NOVEL THERAPEUTIC FUSION PROTEINS
Document Type and Number:
WIPO Patent Application WO2005014822
Kind Code:
A3
Abstract:
The present invention provides novel therapeutic molecules called Culling Fusion Proteins (CFPs) that allow the continuous removal of therapeutic targets from extracellular space by exploiting the endosome/lysosome intracellular degradation pathway, and the exocytotic pathway in a combined manner. The products of the invention, by appropriately utilizing the cellular endocytosis and exocytosis mechanism, can be recycled multiple times by cells to eliminate undesired molecules, therefore such therapeutic molecules can be administered at low concentration.
Inventors:
YANG MEIJA (US)
Application Number:
PCT/EP2004/051715
Publication Date:
July 14, 2005
Filing Date:
August 04, 2004
Export Citation:
Assignee:
APPLIED RESEARCH SYSTEMS (NL)
YANG MEIJA (US)
YANG MEIJA (US)
International Classes:
C07K14/47; C07K14/74; C07K14/79; C12N15/62; A61K38/00; (IPC1-7): C07K14/705; C12N15/62; A61K38/17
Domestic Patent References:
| WO1996039510A1 | 1996-12-12 | |||
| WO2002024929A2 | 2002-03-28 | |||
| WO2002083840A2 | 2002-10-24 |
Other References:
KIM E S ET AL: "Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 99, no. 17, 20 August 2002 (2002-08-20), pages 11399 - 11404, XP002305400, ISSN: 0027-8424
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