Title:
A NOVEL THIOL REDUCTANT, METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/041541
Kind Code:
A1
Abstract:
The present disclosure relates to a novel thiol reductant having the formula (I), the preparation and the use in the preparation of an antibody with thiol group site-specific modifications with improved homogeneity.
Inventors:
WU LILI (CN)
JI AO (CN)
RAN YAJUN (CN)
SHAO YARU (CN)
WANG YICHENG (CN)
JI AO (CN)
RAN YAJUN (CN)
SHAO YARU (CN)
WANG YICHENG (CN)
Application Number:
PCT/CN2023/114310
Publication Date:
February 29, 2024
Filing Date:
August 22, 2023
Export Citation:
Assignee:
SUZHOU BIOREINNO BIOTECHNOLOGY LTD COMPANY (CN)
International Classes:
C07F9/50; A61K31/662; A61K31/664; A61P35/00; C07K16/00; C07K16/28; C07K16/32
Domestic Patent References:
| WO2022078524A2 | 2022-04-21 |
Foreign References:
| US4315867A | 1982-02-16 | |||
| CN107922477A | 2018-04-17 |
Other References:
LORENZ ANNE, KICKELBICK GUIDO, SCHUBERT ULRICH: "Metal Complexes in Inorganic Matrixes. 18. 1 Phosphanyl-Substituted Titanium and Zirconium Alkoxides for Tethering Metal Complexes on Titania or Zirconia and the X-ray Structure Analysis of Polymeric Zr(OPr)(O 3 SMe) 3", CHEMISTRY OF MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 11, 1 November 1997 (1997-11-01), US , pages 2551 - 2560, XP093144383, ISSN: 0897-4756, DOI: 10.1021/cm9702575
VEITS YU. A., NEGANOVA E. G., VINOGRADOVA O. S.: "Synthesis of o-Diorganylphosphino-substituted Benzoic Acids and Their Derivatives", RUSSIAN JOURNAL OF GENERAL CHEMISTRY, PLEIADES PUBLISHING, MOSCOW, vol. 75, no. 7, 1 July 2005 (2005-07-01), Moscow, pages 1060 - 1068, XP093144384, ISSN: 1070-3632, DOI: 10.1007/s11176-005-0368-x
VEITS YU. A., NEGANOVA E. G., VINOGRADOVA O. S.: "Synthesis of o-Diorganylphosphino-substituted Benzoic Acids and Their Derivatives", RUSSIAN JOURNAL OF GENERAL CHEMISTRY, PLEIADES PUBLISHING, MOSCOW, vol. 75, no. 7, 1 July 2005 (2005-07-01), Moscow, pages 1060 - 1068, XP093144384, ISSN: 1070-3632, DOI: 10.1007/s11176-005-0368-x
Attorney, Agent or Firm:
BEIJING HAN KUN LAW OFFICES (CN)
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