Title:
NOVEL THIOUREA DERIVATIVE AS ACTIVATOR OF RORΑ AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2023/085894
Kind Code:
A1
Abstract:
The present invention relates to a novel thiourea derivative as an activator of RORα and a pharmaceutical composition comprising same. A compound according to the present invention is expected to be effective in the treatment and prevention of metabolic and inflammatory diseases through various in vivo functions of RORα, and is particularly expected to be useful for the treatment and prevention of metabolic diseases including liver fibrosis through inhibition of hepatic stellate cell activity.
More Like This:
| WO/2005/080327 | INSECTICIDAL AND NEMATICIDAL DIFLUOROALKENE DERIVATIVES |
Inventors:
PARK HYEUNG-GEUN (KR)
LEE MI-OCK (KR)
OH DAEHYUN (KR)
KIM HYEON-JI (KR)
CHOI HAENA (KR)
LEE MI-OCK (KR)
OH DAEHYUN (KR)
KIM HYEON-JI (KR)
CHOI HAENA (KR)
Application Number:
PCT/KR2022/017924
Publication Date:
May 19, 2023
Filing Date:
November 15, 2022
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07C335/08; A61K31/17; A61K31/4184; A61K31/4453; A61K31/5375; A61P1/16; A61P3/00; C07D211/34; C07D235/30; C07D295/15
Domestic Patent References:
| WO2001044194A2 | 2001-06-21 | |||
| WO2000031067A1 | 2000-06-02 |
Foreign References:
| KR20070007759A | 2007-01-16 | |||
| KR20160132534A | 2016-11-21 |
Other References:
WOOD MARK E, CANE-HONEYSETT DANIEL J, DOWLE MICHAEL D, COLES SIMON J, HURSTHOUSE MICHAEL B: "Synthetic and structural studies on 1,2,4-dithiazolidine-3,5-dione derivatives", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 1, no. 17, 7 September 2003 (2003-09-07), pages 315 - 323, XP093065016, ISSN: 1477-0520, DOI: 10.1039/b305096c
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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