NOVEL THYROID HORMONE RECEPTOR LIGAND, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND USE THEREOF

WIPO Patent Application WO/2003/064369

A1

It is intended to provide compounds represented by the following general formula (I) which have a high affinity for human thyroid hormone receptors, in particular, human thyroid hormone receptor β, medicinal compositions containing the same, and use thereof: (I) wherein W represents O, S(O)_m, CH₂, etc.; R¹ represents halogeno, lower alkyl, halo(lower alkyl), CN, etc.; R² represents hydrogen, halogeno, lower alkyl, etc.; R³ represents hydroxy, etc.; R⁴ represents hydrogen, halogeno, alkyl, halo(lower alkyl), substituted alkyl, aryl, aralkyl, alkoxy, substituted alkoxy, alkanoyl, aroyl, -CONR⁷(R⁸), -S(O)_mR⁹, -SO₂NR⁷(R⁸), etc.; R⁵ represents hydrogen, halogeno, alkyl, substituted alkyl, etc.; and A represents -N(R⁶)CO-A¹-COR¹⁰, etc.

JP2684561	INDUSTRIAL APPLICABILITY INDUSTRIAL APPLICABILITY
JP2000510874	INDUSTRIAL APPLICABILITY: Solid, non-deliquescent formulation of sodium valproate
WO/1997/045113	NSAIDS FOR REGULATING THE REPRODUCTIVE CYCLE OF DOMESTICATED ANIMALS

SHIOHARA HIROAKI (JP)
NAKAMURA TETSUYA (JP)
KIKUCHI NORIHIKO (JP)
OZAWA TOMONAGA (JP)
KITAZAWA MAKIO (JP)

PCT/JP2003/000772

August 07, 2003

January 28, 2003

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KISSEI PHARMACEUTICAL (JP)
SHIOHARA HIROAKI (JP)
NAKAMURA TETSUYA (JP)
KIKUCHI NORIHIKO (JP)
OZAWA TOMONAGA (JP)
KITAZAWA MAKIO (JP)

A61K31/19; A61K31/22; A61K31/223; A61K31/225; A61K31/27; A61K31/341; A61K31/351; A61K31/40; A61K31/426; A61K31/44; A61K31/4406; A61K31/50; A61K31/5375; A61K31/54; A61P1/16; A61P3/04; A61P3/10; A61P5/14; A61P5/16; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P17/00; A61P17/06; A61P19/10; A61P25/24; A61P27/06; A61P35/00; A61P37/08; A61P43/00; C07C59/72; C07C233/25; C07C233/56; C07C235/66; C07C309/65; C07C311/29; C07C317/22; C07C323/41; C07C323/67; C07D209/08; C07D213/75; C07D213/76; C07D237/14; C07D249/12; C07D253/075; C07D257/04; C07D257/06; C07D271/07; C07D277/24; C07D277/34; C07D295/13; C07D295/192; C07D295/26; C07D307/12; C07D309/06; C07D403/12; C07D413/12; C07D417/12; C07D271/06; (IPC1-7): C07C59/72; A61K31/19; A61K31/22; A61K31/223; A61K31/225; A61K31/27; A61K31/341; A61K31/351; A61K31/40; A61K31/426; A61K31/44; A61K31/4406; A61K31/50; A61K31/5375; A61K31/54; A61P1/16; A61P3/04; A61P3/10; A61P5/14; A61P5/16; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P17/00; A61P17/06; A61P19/10; A61P25/24; A61P27/06; A61P35/00; A61P37/08; A61P43/00; C07C233/25; C07C233/56; C07C235/52; C07C235/62; C07C309/65; C07C311/29; C07C317/22; C07C323/41; C07C323/67; C07D213/30; C07D237/14; C07D257/06; C07D277/24; C07D295/18; C07D295/22; C07D307/12; C07D309/06; C07D401/12; C07D403/12

WO2000051971A1	2000-09-08
WO2000039077A2	2000-07-06
WO2000007972A1	2000-02-17
WO2000051971A1	2000-09-08

EP1033364A1

2000-09-06

See also references of EP 1471049A4
ANATEM. ET AL., WEST. AFR. J. MED., vol. 17, no. 4, 1998, pages 248 - 54
SANTALUCIA T. ET AL., J. MOL. BIOL., vol. 314, no. 2, 2001, pages 195 - 204
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ALTSHULER LL. ET AL., AM. J. PSYCHIATRY, vol. 158, no. 10, 2001, pages 1617 - 22
DORDING CM, PSYCHIATR. CLIN. NORTH. AM., vol. 23, no. 4, 2000, pages 743 - 55
KIRKEGAARD C, EUR. J. ENDOCRINOL., vol. 138, 1998, pages 1 - 9
JAMSEN K, ACTA OPHTHALMOL. SCAND., vol. 74, no. 5, 1996, pages 456 - 60
TAMM ER., J. GLAUCOMA, vol. 10, no. 4, 2001, pages 329 - 39
POLANSKY JR. ET AL., EYE, vol. 14, no. 3B, 2000, pages 503 - 14
WIKSTROM L. ET AL., EMBO J., vol. 17, 1998, pages 455
JOHANSSON C. ET AL., AM. J. PHYSIOL., vol. 275, 1998, pages R640

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