Title:
NOVEL TREATMENT AND PREVENTION OF SARCOPENIA-RELATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2022/092294
Kind Code:
A1
Abstract:
The present disclosure has solved problems associated with the TGF-β family or the like, which is called Myostatin/GDF-8 as a molecular mechanism and targeted by sarcopenia, by evaluating a pharmaceutical product in physiological aging models, and in particular, by evaluating an increase in muscle mass and an increase in muscle strength; and has overcome harmful effects by applying targets of diseases different from sarcopenia such as dystrophia. The present disclosure has unexpectedly found a use for an OK-1-related compound as a sarcopenia treatment method through a pathway different from that of Wnt signal (proliferation of muscle stem cells) associated with Wnt/β-catenin inhibition, and is thus provided due to the findings.
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Inventors:
HAYANO MOTOSHI (JP)
KOUJI HIROYUKI (JP)
KOUJI HIROYUKI (JP)
Application Number:
PCT/JP2021/040137
Publication Date:
May 05, 2022
Filing Date:
October 29, 2021
Export Citation:
Assignee:
UNIV KEIO (JP)
OITA UNIV INSTITUTE OF ADVANCED MEDICINE INC (JP)
OITA UNIV INSTITUTE OF ADVANCED MEDICINE INC (JP)
International Classes:
A61K31/675; A61K31/519; A61K31/53; A61K31/551; A61P1/00; A61P3/00; A61P5/00; A61P9/00; A61P11/00; A61P13/00; A61P15/00; A61P19/10; A61P21/00; A61P25/00; A61P25/02; A61P25/28; A61P35/00
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AROUNLEUT PBIALEK PLIANG LFUPADHYAY SFULZELE SJOHNSON MELSALANTY MISALES CMHAMRICK MW: "A myostatin inhibitor (propeptide-Fc) increases muscle mass and muscle fiber size in aged mice but does not increase bone density or bone strength", EXP GERONTOL, vol. 48, no. 9, September 2013 (2013-09-01), pages 898 - 904, XP055521456, DOI: 10.1016/j.exger.2013.06.004
HOFFMANN CWEIGERT C: "Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations", COLD SPRING HARB PERSPECT MED., vol. 7, no. 11, 1 November 2017 (2017-11-01), pages a029793, Retrieved from the Internet
C. G. WERMUTH: "The Practice of Medicinal Chemistry", 2015, ACADEMIC PRESS
T. W. GREENEP. G. M. WUTS: "Comprehensive Organic Transformations", 1999, JOHN WILEY AND SONS, INC.
ZALOOM ET AL., J. ORG. CHEM., vol. 46, 1981, pages 5173 - 76
JIKKEN KAGAKU KOZA: "Remington's The Science and Practice of Pharmacy", vol. 1, 2006, LIPPINCOTT, WILLIAMS & WILKINS, BALTIMORE
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS WILKINS
YOSHIYAMA, CLINICAL NEUROLOGY, vol. 48, 2008, pages 910 - 912
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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