NOVEL TRIAZOLE DERIVATIVE AND ANTIMYCOTIC AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT

WIPO Patent Application WO/1995/026343

A1

An antimycotic triazole derivative represented by general formula (I), a physiologically acceptable salt thereof, and an antimycotic agent containing the same as the active ingredient: wherein R1 and R2 represent each independently hydrogen, lower alkyl or cycloalkyl, or R1 and R2 are combined together to represent alkylene; R3 represents lower alkyl, cycloalkyl, alkyl having a double bond(s), optionally substituted heterocycle or -NR5R6; R5 represents hydrogen or lower alkyl and R6 represents optionally substituted heterocycle, or R5 and R6 are combined together to represent sulfur-containing alkylene; R4 represents hydrogen or lower alkyl; X1 represents hydrogen, halogen or trifluoromethyl; X2 represents hydrogen or halogen; and n represents 0 to 2. These substances have a remarkably potent antimycotic activity and are useful for curing animal and human superficial and deep-seated mycoses.

TOMARI MASAZUMI (JP)
SAKUMA OSAMU (JP)
OHTO HIROYUKI (JP)
NAGAOKA KAZUHIKO (JP)
TSUJI MICHINORI (JP)
OSAKA YOKO (JP)
TAKAGI ATSUSHI (JP)

PCT/JP1995/000597

October 05, 1995

March 29, 1995

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TOKYO TANABE CO (JP)
TOMARI MASAZUMI (JP)
SAKUMA OSAMU (JP)
OHTO HIROYUKI (JP)
NAGAOKA KAZUHIKO (JP)
TSUJI MICHINORI (JP)
OSAKA YOKO (JP)
TAKAGI ATSUSHI (JP)

C07D249/08; C07D521/00; (IPC1-7): C07D249/08; A61K31/41; A61K31/425; A61K31/44; A61K31/54; C07D401/12; C07D405/12; C07D409/12; C07D417/12

JPH06247944A	1994-09-06
JPH06128239A	1994-05-10
JPH05345768A	1993-12-27
JPH05230038A	1993-09-07
JPH054975A	1993-01-14
JPH04356471A	1992-12-10
JPH03223266A	1991-10-02

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