NOVEL TRIAZOLO PYRIDAZINE DERIVATIVE AND USE THEREFOR

WIPO Patent Application WO/2013/133556

A1

The present invention relates to a novel triazolo pyridazine derivative or a pharmaceutically acceptable salt thereof, to a pharmaceutical composition for inhibiting c-Met tyrosine kinase activity and a pharmaceutical composition for preventing or treating an abnormal proliferation disorder (hyperproliferative disorder) comprising same as an active ingredient, and to a method for preventing or treating an abnormal proliferation disorder (hyperproliferative disorder) comprising a step of administering a pharmaceutically effective amount of the pharmaceutical composition to a subject in need thereof. The present invention can advantageously be used as a therapeutic agent for various abnormal proliferation disorders such as cancer, psoriasis, rheumatoid arthritis and diabetic retinopathy which are associated with excessive cell proliferation and growth due to irregular kinase activity by effectively suppressing the activity of c-Met tyrosine kinase.

JUNG HEE JUNG (KR)
KIM HYUNG RAE (KR)
HA JAE DU (KR)
LEE CHONG OCK (KR)
CHO SUNG YUN (KR)
CHOI SANG UN (KR)
LEE JONG KOOK (KR)
PARK CHI HOON (KR)

PCT/KR2013/001443

September 12, 2013

February 22, 2013

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KOREA RES INST CHEM TECH (KR)
HANDOK PHARMACEUTICALS CO LTD (KR)

C07D498/04; A61K31/5025; A61P35/00; C07D487/04

WO2008051805A2	2008-05-02
WO2010072301A1	2010-07-01
WO2007075567A1	2007-07-05
WO2009005675A1	2009-01-08

YANG, Boo-Hyun (Chungdong Building1659-2 Inhundong, Gwanak-gu, Seoul 151-832, KR)

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