Title:
NOVEL TRICYCLIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2019/080941
Kind Code:
A1
Abstract:
This invention relates to certain novel tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors, their synthesis and their use for treating diseases. More particularly, this invention is directed to fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.
Inventors:
FANG HAIQUAN (CN)
ZHOU WENLAI (CN)
HU SHAOJING (CN)
CHEN MINGMING (CN)
YANG GUIQUN (CN)
WANG YANPING (CN)
DU YUELEI (CN)
LI QINGLONG (CN)
WU TONG (CN)
WU LINGJUN (CN)
LI HAIJUN (CN)
LONG WEI (CN)
ZHOU WENLAI (CN)
HU SHAOJING (CN)
CHEN MINGMING (CN)
YANG GUIQUN (CN)
WANG YANPING (CN)
DU YUELEI (CN)
LI QINGLONG (CN)
WU TONG (CN)
WU LINGJUN (CN)
LI HAIJUN (CN)
LONG WEI (CN)
Application Number:
PCT/CN2018/112386
Publication Date:
May 02, 2019
Filing Date:
October 29, 2018
Export Citation:
Assignee:
JACOBIO BETA PHARMACEUTICALS CO LTD (CN)
JACOBIO ALPHA PHARMACEUTICALS CO LTD (CN)
JACOBIO PHARMACEUTICALS CO LTD (CN)
JACOBIO ALPHA PHARMACEUTICALS CO LTD (CN)
JACOBIO PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K51/04; C07D513/04; A61P25/00; A61P25/16; A61P35/00; A61P37/00; C07D498/14; C07D513/14
Domestic Patent References:
| WO2010011964A2 | 2010-01-28 |
Foreign References:
| US5367077A | 1994-11-22 |
Other References:
RATNI, HASSEN ET AL.: "Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 6 February 2009 (2009-02-06), pages 1654 - 1657, XP026005848, DOI: doi:10.1016/j.bmcl.2009.01.109
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