Title:
NOVEL TRICYCLIC NUCLEOSIDES OR NUCLEOTIDES AS THERAPEUTIC AGENTS
Document Type and Number:
WIPO Patent Application WO2005021568
Kind Code:
A3
Abstract:
Nucelosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
Inventors:
COOK PHILLIP DAN (US)
EWING GREGORY (US)
JIN YI (US)
LAMBERT JOHN (US)
PRHAVC MARIJA (US)
RAJAPPAN VASANTHAKUMAR (US)
RAJWANSHI VIVEK K (US)
SAKTHIVEL KANDASAMY (US)
EWING GREGORY (US)
JIN YI (US)
LAMBERT JOHN (US)
PRHAVC MARIJA (US)
RAJAPPAN VASANTHAKUMAR (US)
RAJWANSHI VIVEK K (US)
SAKTHIVEL KANDASAMY (US)
Application Number:
PCT/US2004/027819
Publication Date:
April 21, 2005
Filing Date:
August 27, 2004
Export Citation:
Assignee:
BIOTA INC (US)
COOK PHILLIP DAN (US)
EWING GREGORY (US)
JIN YI (US)
LAMBERT JOHN (US)
PRHAVC MARIJA (US)
RAJAPPAN VASANTHAKUMAR (US)
RAJWANSHI VIVEK K (US)
SAKTHIVEL KANDASAMY (US)
COOK PHILLIP DAN (US)
EWING GREGORY (US)
JIN YI (US)
LAMBERT JOHN (US)
PRHAVC MARIJA (US)
RAJAPPAN VASANTHAKUMAR (US)
RAJWANSHI VIVEK K (US)
SAKTHIVEL KANDASAMY (US)
International Classes:
A61P31/12; C07H19/23; (IPC1-7): C07H19/23; A61K31/7064; A61P31/12
Domestic Patent References:
| WO1998043991A1 | 1998-10-08 |
Foreign References:
| US20030008841A1 | 2003-01-09 |
Other References:
SEELA M AND ZULAUF M: "Synthesis of 7-alkynylated 8-aza-7-deaza-2'-deoxyadenosines via the Pd-catalysed cross-coupling reaction", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY. LETCHWORTH, GB, no. 19, 1998, pages 3233 - 3239, XP002161221, ISSN: 0300-922X
A.R.H. ARAUJO ET AL.: "Synthesis and applications of a tricyclic analogue of N6-methoxy-2,6-diamino-2'-deoxyriboside", COLLECTION SYMPOSIUM SERIES, vol. 5, 2002, pages 328 - 331, XP008043388
F. SEELA ET AL.: "7-Substituted 7-deaza-2'-deoxyadenosines and 8-aza-7-deaza-2'-deoxyadenosines: Fluorescence of DNA-Base Analogues Induced by the 7-Alkynyl Side Chain", HELV. CHIM. ACTA, vol. 83, 2000, pages 910 - 927, XP002318798
D.M. WILLIAMS ET AL.: "Synthesis of a hydrogen-bond-degenerate tricyclic pyrrolopyrimidine nucleoside and of its 5'-triphosphate", J. CHEM. SOC., PERKIN TRANS. 1, 1998, pages 3565 - 3570, XP002318799
A.R.H. ARAUJO ET AL.: "Synthesis and applications of a tricyclic analogue of N6-methoxy-2,6-diamino-2'-deoxyriboside", COLLECTION SYMPOSIUM SERIES, vol. 5, 2002, pages 328 - 331, XP008043388
F. SEELA ET AL.: "7-Substituted 7-deaza-2'-deoxyadenosines and 8-aza-7-deaza-2'-deoxyadenosines: Fluorescence of DNA-Base Analogues Induced by the 7-Alkynyl Side Chain", HELV. CHIM. ACTA, vol. 83, 2000, pages 910 - 927, XP002318798
D.M. WILLIAMS ET AL.: "Synthesis of a hydrogen-bond-degenerate tricyclic pyrrolopyrimidine nucleoside and of its 5'-triphosphate", J. CHEM. SOC., PERKIN TRANS. 1, 1998, pages 3565 - 3570, XP002318799
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