Title:
NOVEL TRICYCLIC PYRIDYL BENZAZEPINE CARBOXAMIDES AND DERIVATIVES THEREOF TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2002083683
Kind Code:
A9
Abstract:
The invention provides novel substituted tricyclic pyridyl carboxamides selected from those of Formula (I) which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea, endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.
Inventors:
FAILLI AMEDEO ARTURO
SHUMSKY JAY SCOTT
CAGGIANO THOMAS JOSEPH
SABATUCCI JOSEPH PETER
MEMOLI KEVIN ANTHONY
TRYBULSKI EUGENE JOHN
SHUMSKY JAY SCOTT
CAGGIANO THOMAS JOSEPH
SABATUCCI JOSEPH PETER
MEMOLI KEVIN ANTHONY
TRYBULSKI EUGENE JOHN
Application Number:
PCT/US2002/011534
Publication Date:
February 26, 2004
Filing Date:
April 11, 2002
Export Citation:
Assignee:
WYETH CORP (US)
International Classes:
A61K31/551; A61K31/5517; A61P5/24; A61P15/00; A61P15/06; A61P25/00; C07D471/14; C07D487/04; C07D487/14; (IPC1-7): C07D487/04; A61K31/5517; C07D487/14; A61K31/495; C07D491/14; A61P25/00
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