Title:
NOVEL TUMOR ANTIGEN-TARGETING ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2023/195767
Kind Code:
A1
Abstract:
The present invention relates to a novel fusion protein in which a monobody specifically binding to a tumor antigen is linked to L-asparaginase for more efficient solid cancer treatment, and a use thereof, and specifically, to a novel asparaginase-based anticancer agent that targets a tumor antigen with enhanced efficiency of drug delivery to tumor tissue, the anticancer agent being a fusion protein in which a calreticulin-specific binding peptide is inserted into at least one of a BC loop or a FG loop of human fibronectin domain III (Fn3), and L-asparaginase is linked to the C-terminus of a recombinant monobody specifically binding to calreticulin.
Inventors:
HONG YEONGJIN (KR)
MIN JUNG-JOON (KR)
YOU SUNG-HWAN (KR)
ZHANG YING (KR)
RUKHSORA SULTONOVA (KR)
MIN JUNG-JOON (KR)
YOU SUNG-HWAN (KR)
ZHANG YING (KR)
RUKHSORA SULTONOVA (KR)
Application Number:
PCT/KR2023/004590
Publication Date:
October 12, 2023
Filing Date:
April 05, 2023
Export Citation:
Assignee:
UNIV NAT CHONNAM IND FOUND (KR)
International Classes:
A61K47/68; A61K38/50; A61P35/00
Domestic Patent References:
| WO2020058749A1 | 2020-03-26 | |||
| WO2022075713A1 | 2022-04-14 |
Foreign References:
| KR101636882B1 | 2016-07-06 | |||
| US20190169589A1 | 2019-06-06 |
Other References:
ZHANG YING, THANGAM RAMAR, YOU SUNG-HWAN, SULTONOVA RUKHSORA D., VENU AKHIL, MIN JUNG-JOON, HONG YEONGJIN: "Engineering Calreticulin-Targeting Monobodies to Detect Immunogenic Cell Death in Cancer Chemotherapy", CANCERS, vol. 13, no. 11, 1 January 2021 (2021-01-01), pages 1 - 18, XP055920476, DOI: 10.3390/cancers13112801
M. SCHLAPSCHY, U. BINDER, C. BORGER, I. THEOBALD, K. WACHINGER, S. KISLING, D. HALLER, A. SKERRA: "PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins", PROTEIN ENGINEERING DESIGN AND SELECTION, IRL PRESS, vol. 26, no. 8, 1 August 2013 (2013-08-01), pages 489 - 501, XP055195431, ISSN: 17410126, DOI: 10.1093/protein/gzt023
ZHANG YING, SULTONOVA RUKHSORA D., YOU SUNG-HWAN, CHOI YOONJOO, KIM SO-YOUNG, LEE WAN-SIK, SEONG JIHYOUN, MIN JUNG-JOON, HONG YEON: "The anticancer effect of PASylated calreticulin-targeting L-ASNase in solid tumor bearing mice with immunogenic cell death-inducing chemotherapy", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 210, 1 April 2023 (2023-04-01), US , pages 115473, XP093097130, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2023.115473
M. SCHLAPSCHY, U. BINDER, C. BORGER, I. THEOBALD, K. WACHINGER, S. KISLING, D. HALLER, A. SKERRA: "PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins", PROTEIN ENGINEERING DESIGN AND SELECTION, IRL PRESS, vol. 26, no. 8, 1 August 2013 (2013-08-01), pages 489 - 501, XP055195431, ISSN: 17410126, DOI: 10.1093/protein/gzt023
ZHANG YING, SULTONOVA RUKHSORA D., YOU SUNG-HWAN, CHOI YOONJOO, KIM SO-YOUNG, LEE WAN-SIK, SEONG JIHYOUN, MIN JUNG-JOON, HONG YEON: "The anticancer effect of PASylated calreticulin-targeting L-ASNase in solid tumor bearing mice with immunogenic cell death-inducing chemotherapy", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 210, 1 April 2023 (2023-04-01), US , pages 115473, XP093097130, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2023.115473
Attorney, Agent or Firm:
HAN, Yun Ho (KR)
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