Title:
NOVEL UREA DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/050238
Kind Code:
A1
Abstract:
Compounds having a urea structure as the basic structure and carrying sulfur and amide bonds in side chains. It has been found out that these compounds have pharmacological effects, in particular, a TNF-$g(a) production inhibitory effect. The above compounds are represented by general formula [I] wherein R?1¿ represents H, alkyl, an aromatic group, R?A¿-CO-, R?C¿-S- or a group of formula [II]; R?2¿, R?3¿ and R?4¿ represent each H, alkyl, alkenyl, cycloalkyl, cycloalkenyl or an aromatic group; R?5¿ and R?6¿ represent each H, alkyl, alkenyl, cycloalkyl, cycloalkenyl or an aromatic group, or R?5¿ and R?6¿ may form together a nonaromatic heterocycle; R?7¿ represents H, alkyl, cycloalkyl, hydroxy, mercapto, phenyl, R?B¿-O-, R?C¿-S-, R?D¿-COS-, R?E¿-OCO-, R?F¿-N(R?G¿)- or -CONHOH; and A?1¿ and A?2¿ represent each an alkylene.
Inventors:
MITA SHIRO (JP)
HORIUCHI MASATO (JP)
BAN MASAKAZU (JP)
SUHARA HIROSHI (JP)
HORIUCHI MASATO (JP)
BAN MASAKAZU (JP)
SUHARA HIROSHI (JP)
Application Number:
PCT/JP1999/001554
Publication Date:
October 07, 1999
Filing Date:
March 25, 1999
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
MITA SHIRO (JP)
HORIUCHI MASATO (JP)
BAN MASAKAZU (JP)
SUHARA HIROSHI (JP)
MITA SHIRO (JP)
HORIUCHI MASATO (JP)
BAN MASAKAZU (JP)
SUHARA HIROSHI (JP)
International Classes:
C07C317/50; C07C323/44; C07C323/59; C07C323/60; C07C327/30; C07C329/06; C07D233/61; C07D295/185; C07D333/32; (IPC1-7): C07C323/44; C07C327/22; C07C329/06; C07C275/16; C07C275/24; C07D213/40; C07D233/61; C07D295/12; C07D295/18; C07F7/18; A61K31/17; A61K31/415; A61K31/44; A61K31/445; A61K31/495; A61K31/595
Foreign References:
| JPH07179414A | 1995-07-18 | |||
| JPH09508115A | 1997-08-19 | |||
| JPH09118658A | 1997-05-06 |
Other References:
See also references of EP 1072591A4
Attorney, Agent or Firm:
Kishimoto, Einosuke (3rd floor 13-18, Nishishinsaibashi 1-chome Chuo-ku Osaka-shi Osaka, JP)
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