NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY

Title:

NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY

Document Type and Number:

WIPO Patent Application WO/2014/145642

Kind Code:

A3

Abstract:

Small molecule inhibitors of Nrf2 and methods of their use are provided for treating or preventing a disease, disorder or condition associated with an Nrf2- regulated pathway. The compound can be administered as a single agent or can be administered to enhance the efficacy of a chemotherapeutic drug and/or radiation therapy.

Inventors:

BISWAL SHYAM S (US)
SINGH ANJU (US)
RASTINEHAD FRAYDOON (US)
SHEN MIN (US)
BOXER MATTHEW B (US)
ZHANG YA-QIN (US)
ROHDE JASON M (US)
OH KYU (US)
VENKANNAGARI SREEDHAR (US)

Application Number:

PCT/US2014/030442

Publication Date:

November 05, 2015

Filing Date:

March 17, 2014

Export Citation:

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Assignee:

UNIV JOHNS HOPKINS (US)
NAT INST HEALTH (US)

International Classes:

C07D277/44; A61K33/24; A61K33/243

Domestic Patent References:

WO2008124000A2	2008-10-16
WO2007076055A2	2007-07-05

Foreign References:

US7595398B2

2009-09-29

Other References:

DATABASE PubChem XP055233546, Database accession no. 3643359
DATABASE PubChem [O] 18 July 2014 (2014-07-18), XP055233548, Database accession no. CID 44182149