Title:
NUCLEAR HORMONE RECEPTOR LIGAND BINDING DOMAIN
Document Type and Number:
WIPO Patent Application WO2002070557
Kind Code:
A3
Abstract:
This invention relates to a novel protein, termed LBDG3, herein identified as a Nuclear Hormone Receptor Ligand Binding Domain and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention and treatment of disease.
Inventors:
FAGAN RICHARD JOSEPH (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
PHILLIPS TOM (GB)
PIERRON VALERIE NATHALIE (GB)
ALLEN KATHRYN ELIZABETH (GB)
ALLEN JANET MARJORIE (GB)
POTTER SARAH JANE (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
PHILLIPS TOM (GB)
PIERRON VALERIE NATHALIE (GB)
ALLEN KATHRYN ELIZABETH (GB)
ALLEN JANET MARJORIE (GB)
POTTER SARAH JANE (GB)
Application Number:
PCT/GB2002/000937
Publication Date:
December 05, 2002
Filing Date:
March 05, 2002
Export Citation:
Assignee:
INPHARMATICA LTD (GB)
FAGAN RICHARD JOSEPH (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
PHILLIPS TOM (GB)
PIERRON VALERIE NATHALIE (GB)
ALLEN KATHRYN ELIZABETH (GB)
ALLEN JANET MARJORIE (GB)
POTTER SARAH JANE (GB)
FAGAN RICHARD JOSEPH (GB)
PHELPS CHRISTOPHER BENJAMIN (GB)
PHILLIPS TOM (GB)
PIERRON VALERIE NATHALIE (GB)
ALLEN KATHRYN ELIZABETH (GB)
ALLEN JANET MARJORIE (GB)
POTTER SARAH JANE (GB)
International Classes:
A61K31/7088; A61K35/76; A61K38/00; A01K67/027; A61K39/00; A61K39/395; A61K45/00; A61K48/00; A61P1/00; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P3/14; A61P5/00; A61P5/14; A61P7/00; A61P7/02; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/10; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P31/18; A61P33/00; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K14/705; C07K14/72; C07K16/28; C12M1/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N37/00; (IPC1-7): C07K14/705; C07K14/72; A61K38/17
Foreign References:
| US5712381A | 1998-01-27 |
Other References:
[online] 15 September 1999 (1999-09-15), POUSTKA A ET AL: "Homo sapiens mRNA; cDNA DKFZp727M231", XP002214288, retrieved from EMBL Database accession no. AL117480
[online] 7 November 1999 (1999-11-07), MOORE M: "Human DNA sequence from clone RP4-756N5 on chromosome 20q11.21-12. Contains gene KIAA1512 for a novel protein similar to myosin heavy chain, the gene encoding a novel protein similar to Trp4-associated protein TAP1 (ABCB2)", XP002214289, retrieved from EMBL Database accession no. AL132825
LAMOUR FRANCOIS P Y ET AL: "Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis.", MOLECULAR AND CELLULAR BIOLOGY, vol. 16, no. 10, 1996, pages 5386 - 5392, XP002214287, ISSN: 0270-7306
[online] 7 November 1999 (1999-11-07), MOORE M: "Human DNA sequence from clone RP4-756N5 on chromosome 20q11.21-12. Contains gene KIAA1512 for a novel protein similar to myosin heavy chain, the gene encoding a novel protein similar to Trp4-associated protein TAP1 (ABCB2)", XP002214289, retrieved from EMBL Database accession no. AL132825
LAMOUR FRANCOIS P Y ET AL: "Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis.", MOLECULAR AND CELLULAR BIOLOGY, vol. 16, no. 10, 1996, pages 5386 - 5392, XP002214287, ISSN: 0270-7306
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