NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

Title:

NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2013/019561

Kind Code:

A8

Abstract:

The invention generally relates to nuclear transport modulators, e.g CRM1inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g, in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

Inventors:

SANDANAYAKA VINCENT P (US)
SHACHAM SHARON (US)
KAUFFMAN MICHAEL (US)
SHECHTER SHARON (US)
MCCAULEY DILARA (US)
LANDESMAN YOSEF (US)
SENAPEDIS WILLIAM (US)
SAINT-MARTIN JEAN-RCHARD (US)

Application Number:

PCT/US2012/048368

Publication Date:

July 04, 2013

Filing Date:

July 26, 2012

Export Citation:

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Assignee:

KARYOPHARM THERAPEUTICS INC (US)
SANDANAYAKA VINCENT P (US)
SHACHAM SHARON (US)
KAUFFMAN MICHAEL (US)
SHECHTER SHARON (US)
MCCAULEY DILARA (US)
LANDESMAN YOSEF (US)
SENAPEDIS WILLIAM (US)
SAINT-MARTIN JEAN-RCHARD (US)

International Classes:

C07D213/50; A61K31/407; A61K31/4196; A61K31/421; A61K31/4439; A61K31/454; A61K31/497; A61K31/506; C07D401/08; C07D401/12; C07D401/14; C07D403/08; C07D403/12; C07D413/12; C07D487/10

Attorney, Agent or Firm:

ABELLEIRA, Susan, M. et al. (Brook Smith & Reynolds, P.C.,530 Virginia Rd, P.O. Box 913, Concord MA, US)

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