Title:
NUCLEIC ACID APTAMERS TARGETING LYMPHOCYTE ACTIVATION GENE 3 (LAG-3) AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/238056
Kind Code:
A1
Abstract:
Nucleic acid aptamers capable of binding to lymphocyte activation gene 3 (LAG-3) and uses thereof for modulating immune responses. Such aptamers may comprise a G-rich motif, for example, GX1GGGX2GGTX3A (SEQ ID No: 1), in which each of X1 and X2 are independently G, C, or absent, and X3 is T or C, or L- (G)n-L', in which n is an integer of 5-9 inclusive, and L and L'are nucleotide segments having complementary sequences. Also provided herein are multimeric nucleic acid aptamers containing a backbone moiety, which comprises a palindromic sequence.
Inventors:
CHANG YI-CHUNG (CN)
CHIANG CHIEN-HAO (CN)
KAO YI-WEI (CN)
CHIANG CHIEN-HAO (CN)
KAO YI-WEI (CN)
Application Number:
PCT/CN2019/090832
Publication Date:
December 19, 2019
Filing Date:
June 12, 2019
Export Citation:
Assignee:
ONENESS BIOTECH CO LTD (CN)
International Classes:
C12N15/115; A61P35/00; A61P37/00; C12Q1/68
Domestic Patent References:
| WO2018039147A1 | 2018-03-01 | |||
| WO2014012479A1 | 2014-01-23 | |||
| WO2018013534A1 | 2018-01-18 | |||
| WO2016073282A1 | 2016-05-12 | |||
| WO2017069291A1 | 2017-04-27 | |||
| WO2016049385A1 | 2016-03-31 | |||
| WO2015048312A1 | 2015-04-02 | |||
| WO2012149024A2 | 2012-11-01 |
Foreign References:
| CN105233291A | 2016-01-13 | |||
| CN102827845A | 2012-12-19 | |||
| CN103443277A | 2013-12-11 |
Other References:
SOLDEVILLA, M.M. ET AL.: "Identification of LAG3 high affinity aptamers by HT-SELEX and Conserved Motif Accumulation (CMA", PLOS ONE, 21 September 2017 (2017-09-21), XP055672847
See also references of EP 3807412A4
See also references of EP 3807412A4
Attorney, Agent or Firm:
CHANG TSI & PARTNERS (CN)
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