Title:
NUCLEIC ACID COMPOUNDS FOR INHIBITING IGF1R GENE EXPRESSION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2008109492
Kind Code:
B1
Abstract:
The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing IGFlR gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to an IGFlR mRNA. In addition, the meroduplex may have at least one uridine is a 5-methyluridine, a nucleoside is a locked nucleic acid, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of an IGFlR gene in a cell or in a subject to treat an IGFlR-related disease.
Inventors:
QUAY STEVEN C (US)
MCSWIGGEN JAMES (US)
VAISH NARENDRA K (US)
AHMADIAN MOHAMMAD (US)
MCSWIGGEN JAMES (US)
VAISH NARENDRA K (US)
AHMADIAN MOHAMMAD (US)
Application Number:
PCT/US2008/055603
Publication Date:
November 20, 2008
Filing Date:
March 03, 2008
Export Citation:
Assignee:
MDRNA INC (US)
QUAY STEVEN C (US)
MCSWIGGEN JAMES (US)
VAISH NARENDRA K (US)
AHMADIAN MOHAMMAD (US)
QUAY STEVEN C (US)
MCSWIGGEN JAMES (US)
VAISH NARENDRA K (US)
AHMADIAN MOHAMMAD (US)
International Classes:
A61K31/713; C12N15/113
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