Title:
NUCLEIC ACID CONSTRUCT COMPRISING UTR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/217267
Kind Code:
A1
Abstract:
The present invention relates to a nucleic acid construct comprising a UTR and use thereof. Specifically, the UTR can significantly improve the expression efficiency of a target gene in the nucleic acid construct. The nucleic acid construct may comprise a nucleic acid sequence expressing, for example, a human hepatocyte growth factor (hHGF), and can be used in a gene therapy for serious lower limb ischemia, diabetic foot, and other diseases.
Inventors:
JIANG JUN (CN)
YANG LINFENG (CN)
CHEN QINJUN (CN)
SONG XIAOYU (CN)
NING WEI (CN)
LIAO CHENG (CN)
YANG LINFENG (CN)
CHEN QINJUN (CN)
SONG XIAOYU (CN)
NING WEI (CN)
LIAO CHENG (CN)
Application Number:
PCT/CN2023/093851
Publication Date:
November 16, 2023
Filing Date:
May 12, 2023
Export Citation:
Assignee:
SHANGHAI REGENELEAD THERAPIES CO LTD (CN)
International Classes:
C12N15/50; A61K9/127; A61K39/215; A61K47/24; A61P31/14
Domestic Patent References:
| WO2013151666A2 | 2013-10-10 | |||
| WO2022066757A1 | 2022-03-31 |
Foreign References:
| CN113186203A | 2021-07-30 | |||
| CN109535243A | 2019-03-29 | |||
| US20180353618A1 | 2018-12-13 | |||
| CN112119162A | 2020-12-22 | |||
| US20170029847A1 | 2017-02-02 |
Other References:
WANG LI, YANG GUODONG, FU HAIYAN, LU XIAOZHAO, WEI MENGYING, LUZFAN: "Construction of cyclooxygenase 2 mRNA 3'UTR luciferase reporter gene vector", CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY., vol. 28, no. 6, 1 January 2012 (2012-01-01), pages 656 - 659, XP093106766, DOI: 10.13423/j.cnki.cjcmi.006454
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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