Title:
NUCLEIC ACID-CONTAINING POWDERY PREPARATION FOR DPI, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/155487
Kind Code:
A1
Abstract:
The present invention provides a powdery composition for the administration using a dry powder inhaler, which contains a single-stranded nucleic acid molecule comprising the nucleotide sequence represented by 5'-UAGCACCAUUUGAAAUCAGUGUU-P-AACACUGAUUUCAAAUGGUGCUAGA-3' (SEQ ID NO: 1) (wherein P represents a proline derivative linker represented by formula (I)) and an excipient, wherein the excipient is preferably lactose and/or mannitol. The composition is a powdery preparation containing a nucleic acid that is effective for the treatment of respiratory diseases, and makes it possible to disperse the nucleic acid in lung tissues uniformly when administered using a DPI.
Inventors:
MATSUMOTO TAKAHIRO (JP)
TOYOFUKU HIDEKAZU (JP)
TOYOFUKU HIDEKAZU (JP)
Application Number:
PCT/JP2018/006194
Publication Date:
August 30, 2018
Filing Date:
February 21, 2018
Export Citation:
Assignee:
BONAC CORP (JP)
International Classes:
A61K31/7105; A61K9/14; A61K9/72; A61K47/10; A61K47/22; A61K47/26; A61K47/54; A61K48/00; A61P11/00
Domestic Patent References:
| WO2015099187A1 | 2015-07-02 | |||
| WO2013174692A1 | 2013-11-28 |
Other References:
MONTGOMERY, R L ET AL.: "MicroRMA mimicry blocks pulmonary fibrosis", EMBO MOLECULAR MEDICINE, vol. 6, no. 10, 19 September 2014 (2014-09-19), pages 1347 - 1356, XP055539071, Retrieved from the Internet
CRYAN, S A ET AL.: "Targeting miRNA-based medicines to cystic fibrosis airway epithelial cells using nanotechnology", JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, vol. 24, no. 3, 18 June 2011 (2011-06-18) - 22 June 2011 (2011-06-22), pages 9 - 10, XP055539100, Retrieved from the Internet
OKUDA, T ET AL.: "Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique", BIOL PHARM BULL, vol. 36, no. 7, 2013, pages 1183 - 1191, XP055539269, Retrieved from the Internet
YAMADA, Y ET AL.: "Novel form of miR-29b suppresses bleomysin- induced pulmonary fibrosis", PLOS ONE, vol. 12, no. 2, 24 February 2017 (2017-02-24), pages 1 - 12, XP055539274, Retrieved from the Internet
CRYAN, S A ET AL.: "Targeting miRNA-based medicines to cystic fibrosis airway epithelial cells using nanotechnology", JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, vol. 24, no. 3, 18 June 2011 (2011-06-18) - 22 June 2011 (2011-06-22), pages 9 - 10, XP055539100, Retrieved from the Internet
OKUDA, T ET AL.: "Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique", BIOL PHARM BULL, vol. 36, no. 7, 2013, pages 1183 - 1191, XP055539269, Retrieved from the Internet
YAMADA, Y ET AL.: "Novel form of miR-29b suppresses bleomysin- induced pulmonary fibrosis", PLOS ONE, vol. 12, no. 2, 24 February 2017 (2017-02-24), pages 1 - 12, XP055539274, Retrieved from the Internet
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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