Title:
NUCLEIC ACID CROSSLINKING REAGENTS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/177976
Kind Code:
A3
Abstract:
Provided herein multifunctional compounds that bind and modify nucleic acids, forming crosslinks between the nucleic acid strands. In particular embodiments, the multifunctional nucleic-acid binding/modifying compounds are selective for nucleic acids of non-viable cells and viruses (i.e., they are excluded from or degraded within viable cells and viruses), and therefore find use in methods for detecting or discriminating viable and non-viable cells/viruses and nucleic acids therefrom.
Inventors:
MONDAL SUBHANJAN (US)
FEIRER NATHAN (US)
ZHOU MIN (US)
SCURRIA MICHAEL (US)
ZHOU WENHUI (US)
GOUELI SAID (US)
CALI JAMES (US)
FEIRER NATHAN (US)
ZHOU MIN (US)
SCURRIA MICHAEL (US)
ZHOU WENHUI (US)
GOUELI SAID (US)
CALI JAMES (US)
Application Number:
PCT/US2023/063488
Publication Date:
October 19, 2023
Filing Date:
March 01, 2023
Export Citation:
Assignee:
PROMEGA CORP (US)
International Classes:
C12Q1/689; C12Q1/70; C07D417/06; C09B23/16
Domestic Patent References:
| WO2022051405A1 | 2022-03-10 |
Foreign References:
| US9850382B1 | 2017-12-26 | |||
| US20180142283A1 | 2018-05-24 | |||
| US5658751A | 1997-08-19 |
Other References:
BOUTORINE ET AL.: "Fluorescent Probes for Nucleic Acid Visualization in Fixed and Live Cells", MOLECULES, vol. 18, 11 December 2013 (2013-12-11), pages 15357 - 15397, XP055187487, DOI: 10.3390/molecules181215357
Attorney, Agent or Firm:
STAPLE, David, W. (US)
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