Title:
NUCLEIC ACID DRUG CAPABLE OF INHIBITING INVASION AND METASTASIS OF CANCER, AND CANCER BIOMARKER
Document Type and Number:
WIPO Patent Application WO/2018/139679
Kind Code:
A1
Abstract:
Disclosed is an anti-tumor agent comprising a SNORA23 gene expression inhibitor. The SNORA23 expression inhibitor may be an oligonucleotide containing at least one nucleoside structure represented by formula (1) (wherein each of "Base" and "A" represents a specific substituent or structure) or a pharmacologically acceptable salt thereof. Also disclosed is an anti-tumor agent comprising an SYNE2 gene expression inhibitor. Also disclosed is a use of SNORA23 as a biomarker, said use being characterized in that SNORA23 in a blood sample is measured for the purpose of detecting the occurrence of invasion or metastasis of a tumor.
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Inventors:
NAKANO KENJI (JP)
CUI LIN (JP)
OBIKA SATOSHI (JP)
YAMAMOTO TSUYOSHI (JP)
CUI LIN (JP)
OBIKA SATOSHI (JP)
YAMAMOTO TSUYOSHI (JP)
Application Number:
PCT/JP2018/003055
Publication Date:
August 02, 2018
Filing Date:
January 30, 2018
Export Citation:
Assignee:
NAKANO KENJI (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
A61K45/00; A61K31/7088; A61P1/00; A61P1/18; A61P11/00; A61P15/00; A61P35/00; A61P35/04; G01N33/574
Domestic Patent References:
| WO2011052436A1 | 2011-05-05 |
Foreign References:
| US20160186270A1 | 2016-06-30 |
Other References:
CREA, F ET AL.: "Integrated analysis of the prostate cancer small-nucleolar transcriptome reveals SNORA55 as a driver of prostate cancer progression", MOL ONCOL, vol. 10, no. 5, 2016, pages 693 - 703, XP029537673
CUI, L ET AL.: "Small nucleolar noncoding RNA SNORA23, up-regulated in human pancreatic ductal adenocarcinoma, regulates expression of spectrin repeat-containing nuclear envelope 2 to promote growth and metastasis of xenograft tumors in mice", GASTROENTEROLOGY, vol. 153, no. 1, July 2017 (2017-07-01), pages 292 - 306, XP085091869
CUI, L ET AL.: "Small nucleolar noncoding RNA SNORA23, up-regulated in human pancreatic ductal adenocarcinoma, regulates expression of spectrin repeat-containing nuclear envelope 2 to promote growth and metastasis of xenograft tumors in mice", GASTROENTEROLOGY, vol. 153, no. 1, July 2017 (2017-07-01), pages 292 - 306, XP085091869
Attorney, Agent or Firm:
NAKAMICHI, Yoshihiro et al. (JP)
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