Title:
NUCLEIC ACID MOLECULE CONTAINING INCORPORATED GENE ENCODING FUSED PROTEIN OF LIGAND AND PROTEIN HAVING PHYSIOLOGICAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2022/153957
Kind Code:
A1
Abstract:
The present invention provides a nucleic acid molecule that contains a gene encoding a fused protein of a ligand and a protein having a physiological activity, said nucleic acid molecule being to be used for expressing the fused protein in a cell, a tissue or in vivo. The present invention also provides the nucleic acid molecule containing a gene encoding the aforesaid fused protein, said nucleic acid molecule being in the form of a plasmid, encapsulated in a recombinant viral virion, or encapsulated in a liposome or a lipid nanoparticle. Further, the present invention pertains to the use of the nucleic acid molecule, which contains a gene encoding the aforesaid fused protein, as a medicine.
Inventors:
KINOSHITA MASAFUMI (JP)
IIZUKA SHUNSUKE (JP)
IMAKIIRE ATSUSHI (JP)
TAKAGI HARUNA (JP)
SONODA HIROYUKI (JP)
IIZUKA SHUNSUKE (JP)
IMAKIIRE ATSUSHI (JP)
TAKAGI HARUNA (JP)
SONODA HIROYUKI (JP)
Application Number:
PCT/JP2022/000466
Publication Date:
July 21, 2022
Filing Date:
January 11, 2022
Export Citation:
Assignee:
JAPAN CHEM RES (JP)
International Classes:
C12N5/0735; A01K67/027; C12N5/074; C12N5/0775; C12N5/0789; C12N5/0797; C12N5/10; C12N7/01; C12N15/113; C12N15/12; C12N15/13; C12N15/34; C12N15/40; C12N15/51; C12N15/62; C12N15/63
Domestic Patent References:
| WO2019226894A1 | 2019-11-28 | |||
| WO2019161059A1 | 2019-08-22 | |||
| WO2016208695A1 | 2016-12-29 | |||
| WO2016208695A1 | 2016-12-29 | |||
| WO2021039644A1 | 2021-03-04 |
Other References:
SONODA H. ET AL., MOL THER., vol. 26, 2018, pages 1366 - 74
ALTSCHUL SF., J MOL. BIOL., vol. 215, 1990, pages 403 - 10
PEARSONLIPMAN, PROC. NATL. ACAD. SCI. USA., vol. 85, 1988, pages 2444
SMITHWATERMAN, ADV. APPL. MATH, vol. 2, 1981, pages 482 - 9
ALTSCHUL SF., J MOL. BIOL., vol. 215, 1990, pages 403 - 10
PEARSONLIPMAN, PROC. NATL. ACAD. SCI. USA., vol. 85, 1988, pages 2444
SMITHWATERMAN, ADV. APPL. MATH, vol. 2, 1981, pages 482 - 9
Attorney, Agent or Firm:
YAMAMOTO, Yoshiki et al. (JP)
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