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Title:
NUCLEIC ACID MOLECULE ENCODING KRAS GENE MUTANT
Document Type and Number:
WIPO Patent Application WO/2022/048574
Kind Code:
A1
Abstract:
Provided are a nucleic acid molecule encoding a Kras gene mutant and an application of an oncolytic herpes simplex virus (oHSV) vector containing said nucleic acid molecule in preparing an anti-tumor drug. The mutant comprises one or more among a Kras G12D mutant, a Kras G13D mutant, a Kras G12V mutant, a Kras G13C mutant, a Kras G12C mutant, a Kras G13A mutant, a Kras G12A mutant, a Kras Q61L mutant, a Kras G12R mutant, a Kras Q61H, a Kras G12S mutant, a Kras Q61R mutant, a Kras A59T mutant, a Kras A146T mutant, a Kras Y64H mutant, and a Kras A18D mutant.

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Inventors:
ZHANG HUA (CN)
HUA JIAN (CN)
CHEN XIAOQING (CN)
LIU YUANYUAN (CN)
Application Number:
PCT/CN2021/116075
Publication Date:
March 10, 2022
Filing Date:
September 01, 2021
Export Citation:
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Assignee:
SPH BIOTHERAPEUTICS HK LTD (CN)
International Classes:
A61K48/00; C12N15/11; A61P35/00; C12N15/63; C12N15/66; C12N15/86
Domestic Patent References:
WO2016053339A12016-04-07
Foreign References:
CN106659705A2017-05-10
CN102108356A2011-06-29
Other References:
YONG-CHEN LU ET AL.: "An Efficient Single- Cell RNA-Seq Approach to Identify Neoantigen- Specific T Cell Receptors", MOL THER., vol. 26, no. 2, 7 February 2018 (2018-02-07), XP002781571
AYUMU ITO ET AL.: "Cancer Neoantigens: A Promising Source of Immunogens for Cancer Immunotherapy", CLINICAL & CELLULAR IMMUNOLOGY, vol. 6, no. 2, 28 April 2015 (2015-04-28), XP055346449, DOI: 10.4172/2155-9899.1000322
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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