Title:
NUCLEIC ACID SEQUENCE EXPRESSING SARS-COV-2 OMICRON MUTANT STRAIN VIRUS ANTIGEN PEPTIDE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/151173
Kind Code:
A1
Abstract:
The present invention provides a nucleic acid sequence expressing a SARS-CoV-2 Omicron mutant strain virus antigen peptide, and a use thereof. The original S gene sequence protein of the Omicron strain cannot be effectively and efficiently expressed in cells. According to the present invention, a novel S gene sequence is obtained by means of optimization on the basis of codon usage bias, such that the S gene sequence can be efficiently expressed in human cells to generate corresponding polypeptides and induce corresponding immunoprotective responses, thereby laying the foundation for research and development of vaccines against the SARS-CoV-2 Omicron strain.
Inventors:
CHEN LING (CN)
YANG CHENCHEN (CN)
WANG QIAN (CN)
GUAN SUHUA (CN)
YANG CHENCHEN (CN)
WANG QIAN (CN)
GUAN SUHUA (CN)
Application Number:
PCT/CN2022/085802
Publication Date:
August 17, 2023
Filing Date:
April 08, 2022
Export Citation:
Assignee:
GUANGZHOU N BIOMED LTD (CN)
International Classes:
C12N15/50; A61K39/215; A61P31/14; C12N5/10; C12N15/861
Foreign References:
| CN114150005A | 2022-03-08 | |||
| CN114150004A | 2022-03-08 | |||
| CN113930452A | 2022-01-14 | |||
| CN112220918A | 2021-01-15 | |||
| CN112206318A | 2021-01-12 | |||
| CN111778264A | 2020-10-16 | |||
| CN111533812A | 2020-08-14 |
Other References:
GARCIA-BELTRAN WILFREDO F.; ST. DENIS KERRI J.; HOELZEMER ANGELIQUE; LAM EVAN C.; NITIDO ADAM D.; SHEEHAN MAEGAN L.; BERRIOS CRIST: "mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant", CELL, ELSEVIER, AMSTERDAM NL, vol. 185, no. 3, 6 January 2022 (2022-01-06), Amsterdam NL , pages 457, XP086949417, ISSN: 0092-8674, DOI: 10.1016/j.cell.2021.12.033
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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