Title:
NUCLEIC ACID VACCINES FOR CORONAVIRUS
Document Type and Number:
WIPO Patent Application WO/2021/204179
Kind Code:
A1
Abstract:
Provided herein are therapeutic nucleic acid molecules for managing, preventing and/or treating infectious diseases caused by coronavirus. Also provided herein are therapeutic compositions, including vaccines and lipid nanoparticles, comprising the therapeutic nucleic acids and related therapeutic methods and uses.
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Inventors:
YING BO (CN)
Application Number:
PCT/CN2021/085883
Publication Date:
October 14, 2021
Filing Date:
April 08, 2021
Export Citation:
Assignee:
SUZHOU ABOGEN BIOSCIENCES CO LTD (CN)
International Classes:
A61K31/7088; A61K39/12; A61P31/14
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XIA JIA ET AL: "Towards an effective mRNA vaccine against 2019-nCoV: demonstration of virus-like particles expressed from an modified mRNA cocktail", 25 February 2020 (2020-02-25), XP055820076, Retrieved from the Internet
DATABASE EMBL [online] EBI; 15 January 2020 (2020-01-15), ZHANG Y.-Z. ET AL: "Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome.", XP055796635, Database accession no. MN908947
HE YUXIAN ET AL: "Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 324, no. 2, 2 October 2004 (2004-10-02), pages 773 - 781, XP028808463, ISSN: 0006-291X, DOI: 10.1016/J.BBRC.2004.09.106
ICKENSTEIN LUDGER M. ET AL: "Lipid-based nanoparticle formulations for small molecules and RNA drugs", EXPERT OPINION ON DRUG DELIVERY, vol. 16, no. 11, 2 November 2019 (2019-11-02), GB, pages 1205 - 1226, XP055820445, ISSN: 1742-5247, DOI: 10.1080/17425247.2019.1669558
ZHANG NA-NA ET AL: "A Thermostable mRNA Vaccine against COVID-19", CELL, vol. 182, no. 5, 23 July 2020 (2020-07-23), Amsterdam NL, pages 1271 - 1283.e16, XP055820115, ISSN: 0092-8674, DOI: 10.1016/j.cell.2020.07.024
POLACK FERNANDO P. ET AL: "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 383, no. 27, 31 December 2020 (2020-12-31), US, pages 2603 - 2615, XP055820495, ISSN: 0028-4793, Retrieved from the Internet
WALLACE ET AL., J. IMMUNOL. METHODS, vol. 248, 2001, pages 167 - 82
"Current Protocols in Molecular Biology", 2003
BUNDGARD, H.: "Design of Prodrugs", 1985, ELSEVIER, pages: 7 - 9,21-24
HIGUCHI, T. ET AL.: "Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
WELLENSIEK ET AL.: "Genome-wide profiling of human cap-independent translation-enhancing elements", NATURE METHODS, vol. 10, no. 8, August 2013 (2013-08-01), pages 747 - 750, XP055658496, DOI: 10.1038/nmeth.2522
CHAPPELL ET AL., PNAS, vol. 101, no. 26, 29 June 2004 (2004-06-29), pages 9590 - 9594
PANEK ET AL., NUCLEIC ACIDS RESEARCH, vol. 41, no. 16, 1 September 2013 (2013-09-01), pages 7625 - 7634
"GenBank", Database accession no. MN908947
RAVETCHKINET, ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 92
CLYNES ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 652 - 56
BRACHER ET AL., J. IMMUNOL. METHODS, vol. 323, 2007, pages 160 - 71
DAERON, ANNU. REV. IMMUNOL., vol. 15, 1997, pages 203 - 34
CAPEL ET AL., IMMUNOMETHODS, vol. 4, 1994, pages 25 - 34
DE HAAS ET AL., J. LAB. CLIN. MED., vol. 126, 1995, pages 330 - 41
GUYER ET AL., J. IMMUNOL., vol. 117, 1976, pages 587 - 93
KIM ET AL., EU. J. IMMUNOL., vol. 24, 1994, pages 2429 - 34
SHIELDS ET AL., J. BIOL. CHEM., vol. 9, no. 2, 2001, pages 6591 - 604
GAZZANO-SANTORO ET AL., J. IMMUNOL. METHODS, vol. 202, 1996, pages 163
IDUSOGIE ET AL., J. IMMUNOL., vol. 164, 2000, pages 4178 - 84
KUBY: "Immunology", 1997
HARLOWLANE, ANTIBODIES: A LABORATORY MANUAL, 1989
"Mol. Biology and Biotechnology: A Comprehensive Desk Reference", 1995
HUSTON ET AL., CELL BIOPHYSICS, vol. 22, 1993, pages 189 - 224
PLIICKTHUNSKERRA, METH. ENZYMOL., vol. 178, 1989, pages 497 - 515
DAY: "Advanced Immunochemistry", 1990
"Physician's Desk Reference", 2014
LI ET AL., ANNU REV VIROL., vol. 3, no. 1, 2016, pages 237 - 261
KORE ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 2013, pages 4570 - 4574
CHAPPEL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 9590 - 9594
ZHOU ET AL., PROC. NATL. ACAD. SCI., vol. 102, 2005, pages 6273 - 6278
NATURE METHODS, vol. 10, no. 8, August 2013 (2013-08-01), pages 747 - 750
KEDDE ET AL.: "A Pumilio-induced RNA structure switch in p27-3'UTR controls miR-221 and miR-222 accessibility", NAT CELL BIOL., vol. 12, no. 10, October 2010 (2010-10-01), pages 1014 - 20
SABNIS ET AL.: "A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates", MOLECULAR THERAPY, vol. 26, no. 6, 2018, XP055644778, DOI: 10.1016/j.ymthe.2018.03.010
"Remington's The Science and Practice of Pharmacy", 2006, LIPPINCOTT, WILLIAMS & WILKINS
LEACH DR ET AL., SCIENCE, vol. 271, 1996, pages 1734 - 1736
TOPALIAN SL, NEJM, vol. 28, 2012, pages 3167 - 75
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AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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