Title:
NUCLEIC ACIDS SIMULTANEOUSLY INHIBITING EXPRESSION OF C-MET GENE AND PD-L1 GENE
Document Type and Number:
WIPO Patent Application WO/2022/191661
Kind Code:
A1
Abstract:
The present invention relates to nucleic acid molecules simultaneously inhibiting the expression of a C-MET gene and a PD-L1 gene, and an anti-cancer pharmaceutical composition comprising same. All of the bispecific nucleic acid molecules of the present invention, designed so that the sense strand inhibits the expression of PD-L1 gene and the antisense strand inhibits the expression of c-MET gene, simultaneously inhibit the expression of a c-MET gene and a PD-L1 gene when actually applied as siRNA or shRNA to various cancer cells and remarkably inhibit the expression of both genes even when applied as shRNA to viruses, and thus are usable as an anti-cancer composition or an anti-cancer adjuvant for a variety of carcinomas, can be locally delivered, and having excellent selectivity.
Inventors:
CHOI JIN WOO (KR)
YOO JUNG KI (KR)
UM KI HWAN (KR)
YOO JUNG KI (KR)
UM KI HWAN (KR)
Application Number:
PCT/KR2022/003454
Publication Date:
September 15, 2022
Filing Date:
March 11, 2022
Export Citation:
Assignee:
CURIGIN CO LTD (KR)
International Classes:
C12N15/113; A61K31/7105; A61P35/00
Domestic Patent References:
| WO2021194180A1 | 2021-09-30 |
Foreign References:
| KR20190009961A | 2019-01-30 | |||
| KR20090014673A | 2009-02-11 | |||
| US20130023578A1 | 2013-01-24 |
Other References:
SUN XIAN, LI CHIA-WEI, WANG WEI-JAN, CHEN MEI-KUANG, LI HUI, LAI YUN-JU, HSU JENNIFER L, KOLLER PAUL B, CHAN LI-CHUAN, LEE PEI-CHI: "Inhibition of c-MET upregulates PD-L1 expression in lung adenocarcinoma", AMERICAN JOURNAL OF CANCER RESEARCH, E-CENTURY PUBLISHING CORPORATION, US, vol. 10, no. 2, 1 February 2020 (2020-02-01), US , pages 564 - 571, XP055965714, ISSN: 2156-6976
JIE ZHANG, MENG DING, KAI XU, LIJUN MAO, JUNIAN ZHENG: "shRNA-armed conditionally replicative adenoviruses: a promising approach for cancer therapy", ONCOTARGET, vol. 7, no. 20, 17 May 2016 (2016-05-17), XP055639905, DOI: 10.18632/oncotarget.8035
JIE ZHANG, MENG DING, KAI XU, LIJUN MAO, JUNIAN ZHENG: "shRNA-armed conditionally replicative adenoviruses: a promising approach for cancer therapy", ONCOTARGET, vol. 7, no. 20, 17 May 2016 (2016-05-17), XP055639905, DOI: 10.18632/oncotarget.8035
Attorney, Agent or Firm:
WIE, Byoung Gap (KR)
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